Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024;30(20):1578-1598.
doi: 10.2174/0113816128283420240409050754.

Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In silico Analyses

Myltykbay S Rysmakhanov  1   2 , Afshin Zare  3 , Aibolat S Smagulov  1 , Nurgul A Abenova  4 , Nadiar M Mussin  1 , Yerlan B Sultangereyev  1   2 , Bazylbek S Zhakiyev  1 , Gani K Kuttymuratov  2 , Mehmet Haberal  5 , Nazanin Jafari  3 , Hanieh Baneshi  3 , Shabnam Bakhshalizadeh  6   7 , Mahdi Mahdipour  8   9 , Farhad Rahmanifar  10 , Amin Tamadon  2   11
Affiliations
Review

Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In silico Analyses

Myltykbay S Rysmakhanov et al. Curr Pharm Des. 2024.

Abstract

Background: Ischemia-reperfusion Injury (IRI) is a complex pathophysiological process with severe consequences, including irreversible loss of renal function. Various intraoperative prevention methods have been proposed to mitigate the harmful effects of warm ischemia and kidney reperfusion.

Aim: This comprehensive analysis provides an overview of pharmacological agents and intraoperative methods for preventing and treating renal IRI.

Methods: Our analysis revealed that eplerenone exhibited the highest binding affinity to crucial targets, including Aldehyde Dehydrogenase (AD), Estrogen Receptor (ER), Klotho protein, Mineralocorticoid Receptor (MR), and Toll-like Receptor 4 (TLR4). This finding indicates eplerenone's potential as a potent preventive agent against IRI, surpassing other available therapeutics like Benzodioxole, Hydrocortisone, Indoles, Nicotinamide adenine dinucleotide, and Niacinamide. In preventing kidney IRI, our comprehensive analysis emphasizes the significance of eplerenone due to its strong binding affinity to key targets involved in the pathogenesis of IRI.

Results: This finding positions eplerenone as a promising candidate for further clinical investigation and consideration for future clinical practice.

Conclusion: The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.

Keywords: Ischemia-reperfusion injury; bibliometric analysis; kidney reperfusion; kidney transplantation; molecular docking; renal resection..

PubMed Disclaimer

References

    1. Łabuś A.; Niemczyk M.; Czyżewski Ł.; Fliszkiewicz M.; Kulesza A.; Mucha K.; Pączek L.; Costs of long-term post-transplantation care in kidney transplant recipients. Ann Transplant 2019,24,252-259 - DOI - PubMed
    1. Axelrod D.A.; Schnitzler M.A.; Xiao H.; Irish W.; Tuttle-Newhall E.; Chang S.H.; Kasiske B.L.; Alhamad T.; Lentine K.L.; An economic assessment of contemporary kidney transplant practice. Am J Transplant 2018,18(5),1168-1176 - DOI - PubMed
    1. Jensen C.E.; Sørensen P.; Petersen K.D.; In Denmark kidney transplantation is more cost-effective than dialysis. Dan Med J 2014,61(3),A4796 - PubMed
    1. Qiu L.; Zhang Z.J.; Therapeutic strategies of kidney transplant ischemia reperfusion injury: Insight from mouse models. Biomed J Sci Tech Res 2019,14(5),002617 - PubMed
    1. Eleftheriadis T.; Pissas G.; Filippidis G.; Liakopoulos V.; Stefanidis I.; Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor. Mol Med Rep 2020,23(1),1 - DOI - PubMed

LinkOut - more resources