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Review
. 2024 May;25(5):679-701.
doi: 10.1007/s11864-024-01203-6. Epub 2024 Apr 27.

Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods

Ziyu Kuang #  1   2 , Miao Kong #  1 , Ningzhe Yan #  1   2 , Xinyi Ma  1 , Min Wu  3 , Jie Li  4
Affiliations
Review

Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods

Ziyu Kuang et al. Curr Treat Options Oncol. 2024 May.

Abstract

Cardio-oncology is an emerging interdisciplinary field dedicated to the early detection and treatment of adverse cardiovascular events associated with anticancer treatment, and current clinical management of anticancer-treatment-related cardiovascular toxicity (CTR-CVT) remains limited by a lack of detailed phenotypic data. However, the promise of diagnosing CTR-CVT using deep phenotyping has emerged with the development of precision medicine, particularly the use of omics-based methodologies to discover sensitive biomarkers of the disease. In the future, combining information produced by a variety of omics methodologies could expand the clinical practice of cardio-oncology. In this review, we demonstrate how omics approaches can improve our comprehension of CTR-CVT deep phenotyping, discuss the positive and negative aspects of available omics approaches for CTR-CVT diagnosis, and outline how to integrate multiple sets of omics data into individualized monitoring and treatment. This will offer a reliable technical route for lowering cardiovascular morbidity and mortality in cancer patients and survivors.

Keywords: Cardio-oncology; Cardiotoxicity; Omics; Precision medicine.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Omics classification for the diagnosis of CTR-CVD (Created with BioRender.com).
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