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Meta-Analysis
. 2025 Feb;203(2):635-645.
doi: 10.1007/s12011-024-04197-2. Epub 2024 Apr 27.

Meta-analysis of the Relationship Between Zinc and Copper in Patients with Osteoarthritis

Haowei Zhou  1 , Yuchen Zhang  1 , Tian Tian  1 , Bingqian Wang  1 , Yalei Pan  2   3
Affiliations
Meta-Analysis

Meta-analysis of the Relationship Between Zinc and Copper in Patients with Osteoarthritis

Haowei Zhou et al. Biol Trace Elem Res. 2025 Feb.

Abstract

This study aims to explore the relationship between osteoarthritis and the trace elements zinc and copper and to provide a theoretical basis for research on the related mechanisms for the prevention, diagnosis, and treatment of osteoarthritis. We searched all the literature indexed in Web Of Science, Embase, and PubMed as of January 10, 2024, summarized the zinc and copper detection indexes in patients with osteoarthritis, obtained clinical data through literature screening, quality assessment, and data extraction, and analyzed the data using Revman 5.4. A total of 13 papers were included in this study, totaling 7983 study subjects. These were divided into osteoarthritis and healthy control groups. The results from the meta-analysis showed that in patients with osteoarthritis, circulating copper levels, but not zinc levels, were significantly higher compared to healthy individuals. The level of copper in the blood of patients with osteoarthritis is significantly higher than that of healthy people.

Keywords: Copper; Osteoarthritis; Trace element; Zinc.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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