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Review
. 2024 Jun:175:116618.
doi: 10.1016/j.biopha.2024.116618. Epub 2024 Apr 27.

Diagnostic and therapeutic value of human serpin family proteins

Sabina Janciauskiene  1 , Urszula Lechowicz  2 , Magdalena Pelc  2 , Beata Olejnicka  3 , Joanna Chorostowska-Wynimko  4
Affiliations
Free article
Review

Diagnostic and therapeutic value of human serpin family proteins

Sabina Janciauskiene et al. Biomed Pharmacother. 2024 Jun.
Free article

Abstract

SERPIN (serine proteinase inhibitors) is an acronym for the superfamily of structurally similar proteins found in animals, plants, bacteria, viruses, and archaea. Over 1500 SERPINs are known in nature, while only 37 SERPINs are found in humans, which participate in inflammation, coagulation, angiogenesis, cell viability, and other pathophysiological processes. Both qualitative or quantitative deficiencies or overexpression and/or abnormal accumulation of SERPIN can lead to diseases commonly referred to as "serpinopathies". Hence, strategies involving SERPIN supplementation, elimination, or correction are utilized and/or under consideration. In this review, we discuss relationships between certain SERPINs and diseases as well as putative strategies for the clinical explorations of SERPINs.

Keywords: Hereditary diseases; Inflammation; Protease inhibitors; SERPINs; Serpinopathies; Therapeutics.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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