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. 2024 Mar;17(3):700-704.
doi: 10.14202/vetworld.2024.700-704. Epub 2024 Mar 25.

Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats

Carmen R Silva-Correa  1 , Víctor E Villarreal-La Torre  1 , Gladys E Lozano-Ciudad  1 , Ricardo M Gómez-Arce  2 , Julio A Castañeda-Carranza  2 , Deivy Y Dionicio-Rosado  2 , María E Cotrina-León  3 , William A Sagástegui-Guarniz  1 , César D Gamarra-Sánchez  1 , José L Cruzado-Razco  1
Affiliations

Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats

Carmen R Silva-Correa et al. Vet World. 2024 Mar.

Abstract

Background and aims: Ambrosia arborescens Mill. (A. arborescens) is an aromatic plant used in traditional medicine as an anti-inflammatory, anti-tussive, anti-rheumatic, and anti-diarrheal agent. This study aimed to evaluate the effect of A. arborescens Mill. on a Rattus norvegicus var. albinus-induced breast cancer model.

Materials and methods: We collected A. arborescens from the province of Julcán, La Libertad Region, Per, and prepared an ethanolic extract using pulverized leaves macerated in 96° ethanol for 72 h with magnetic stirring. In the evaluation of anticancer activity, four experimental groups with 10 female rats each were formed: Group I (Control-7,12-dimethylbenz[a]anthracene [DMBA]), which received DMBA (single dose) and physiological saline solution for 4 months, and Groups II, III, and IV, which received DMBA (single dose) and 200, 400, and 600 mg/kg/day of the ethanolic extract of A. arborescens, respectively, for 4 months.

Results: The DMBA control group presented histological characteristics of ductal carcinoma in situ with necrotic and inflammatory areas, whereas the A. arborescens extract group showed a decrease in tumor volume and recovery of the ductal duct.

Conclusion: Ethanol extract of A. arborescens leaves decreases tumor development in rats with induced breast cancer, and this effect is dose-dependent.

Keywords: 7,12-dimethylbenz[a]anthracene; Ambrosia arborescens; breast carcinoma in situ; cancer; rat.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure-1
Figure-1
Effect of Ambrosia arborescens Mill. on (a) tumor latency (b) and tumor volume in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer. All data are presented as mean ± standard deviation, n = 10 per group, p < 0.05, Analysis of Variance, post hoc Tukey Honestly Significant Difference test.
Figure-2
Figure-2
Photomicrographs of histological changes in breast tissue (hematoxylin and eosin, 400×).
See this image and copyright information in PMC

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