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Case Reports
. 2024 Apr 25;2024(4):omae035.
doi: 10.1093/omcr/omae035. eCollection 2024 Apr.

Amelanotic melanoma in a kidney transplant patient: a rare case report

Yara Melhem  1 , Seham Khattab  1 , Moatasem Hussein Al-Janabi  2 , Hussein Saeid  3 , Issa Ahmad  4 , Fouz Hasan  1
Affiliations
Case Reports

Amelanotic melanoma in a kidney transplant patient: a rare case report

Yara Melhem et al. Oxf Med Case Reports. .

Abstract

Immunosuppressed individuals face a significantly elevated risk of developing aggressive cutaneous malignancies, often surpassing the aggressiveness observed in immunocompetent counterparts. Our patient exhibited several risk factors associated with melanoma development in renal recipients, including skin type, sun exposure, and the duration of immunosuppression. The determination of staging holds paramount importance as it directly influences both prognosis and subsequent management. It is crucial to handle suspected lesions with caution in these patients to facilitate early melanoma detection and enhance overall prognosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A large non-pigmented crusted nodule on the thigh in a blond 45-year-old man.
Figure 2
Figure 2
Hematoxylin and eosin stain (A–D) Microscopic images of the lesion. (A) Proliferating of malignant spindle cells with epidermal ulceration (40×). (B) Tumor cells invade subcutaneous fatty tissue (100×). (C and D) Pleomorphism, prominent nuclei, and mitotic figures are seen (200× and 400×).
Figure 3
Figure 3
Immunohistochemical stain image (A–D). The tumor cells are positive for HMB-45 (40×, 100×, 200×, 200×).
Figure 4
Figure 4
A clinical image shows multiple enlarged left inguinal lymph nodes.
See this image and copyright information in PMC

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