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Case Reports
. 2024 Mar 26;16(3):e57004.
doi: 10.7759/cureus.57004. eCollection 2024 Mar.

Bilateral Naevus of Ito and Ota With Palatal Involvement

Niranjana S Pillai  1 , Yash Buccha  1 , Rahul S Nair  2 , Rohit Kothari  1 , Nishtha Malik  1
Affiliations
Case Reports

Bilateral Naevus of Ito and Ota With Palatal Involvement

Niranjana S Pillai et al. Cureus. .

Abstract

Naevus of Ito and naevus of Ota are benign dermal melanocytoses with similar pathogenic mechanisms of failure in the melanocyte migration to typical locations within the basal layer from neural crest cells and differ in distribution. Bilateral and oral mucosal involvement of naevus of Ota can occur but is infrequent. Naevus of Ito is seldom associated with naevus of Ota and extracutaneous manifestations. A review of the English literature showed 14 cases of naevus of Ota with palatal involvement. None showed bilateral involvement of both naevi with oral involvement. Here we report the case of bilateral naevus of Ito and bilateral naevus of Ota with palatal involvement. A 32-year-old male came to us with naevus of Ito on both sides of his back and naevus of Ota on both sides of his face involving the sclera of both eyes with a bluish lesion along the midline of the hard palate.

Keywords: acquired nevi; congenital melanocytic nevi; hori naevus; naevus of ito; naevus of ota.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Naevus of Ota
a, b: Bluish-grey colored macules to patches present over the periorbital area, cheeks extending up to the temples and forehead on the left and right side respectively
Figure 2
Figure 2. Naevus of Ito
Bluish-grey speckled macules to patches on bilateral lumbar, infrascapular, and left scapular area
Figure 3
Figure 3. Naevus of Ota with mucosal involvement
a: Deep-blue irregular mottled patch on the hard palate; b: Bluish-grey discoloration of bilateral sclera
Figure 4
Figure 4. Dermoscopic images
a: Naevus of Ota showing brownish gray structureless areas in patchy distribution (arrow) with scattered brown dots (triangle), terminal hair with perifollicular hyperpigmentation (circle), and four dot clods (square); b: Naevus of Ito showing brownish gray structureless areas in patchy distribution (arrow) with scattered brown dots (triangle), scaling (star), terminal hair with perifollicular hyperpigmentation (circle) and four dot clods (square)
Figure 5
Figure 5. Histopathological image
The black arrow shows increased basal pigmentation and the pink arrow shows scattered long slender, pigmented dendritic dermal melanocytes
Figure 6
Figure 6. Post-treatment images
a: Showing Naevus of Ota; b: Showing Naevus of Ito
See this image and copyright information in PMC

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References

    1. Bilateral nevus of Ota with palatal involvement, unilateral nevus of Ito, and a port-wine stain: a rare presentation. Mohta A, Kushwaha RK, Kumari P, Shamra MK, Jain SK. Our Dermatol Online. 2022;13:197–201.
    1. Natural history of nevus of Ota. Hidano A, Kajima H, Ikeda S, Mizutani H, Miyasato H, Niimura M. https://pubmed.ncbi.nlm.nih.gov/6018994/ Arch Dermatol. 1967;95:187–195. - PubMed
    1. Nevus of Ota with buccal mucosal pigmentation: a rare case. Shetty SR, Subhas BG, Rao KA, Castellino R. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177382/ Dent Res J (Isfahan) 2011;8:52–55. - PMC - PubMed
    1. Dermal dendritic melanocytic proliferations: an update. Zembowicz A, Mihm MC. Histopathology. 2004;45:433–451. - PubMed
    1. The naevus of Ota. Swann PG, Kwong E. Clin Exp Optom. 2010;93:264–267. - PubMed

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