Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Apr 29;4(4):CD013875.
doi: 10.1002/14651858.CD013875.pub2.

Autologous platelet-rich plasma for assisted reproduction

Dennis Vaidakis  1 , Michail Papapanou  2   3 , Charalampos S Siristatidis  4
Affiliations
Meta-Analysis

Autologous platelet-rich plasma for assisted reproduction

Dennis Vaidakis et al. Cochrane Database Syst Rev. .

Abstract

Background: Autologous platelet-rich plasma (PRP) consists of plasma and a concentrate of platelets extracted from fresh whole blood of the person being treated. Research has suggested that intrauterine or intraovarian infusion/injection of PRP before embryo transfer may improve endometrial receptivity and response to ovarian stimulation in women undergoing assisted reproduction. We compared these interventions to standard treatment, placebo, or other interventions (mechanical or pharmacological).

Objectives: To assess the effectiveness and safety of intrauterine and intraovarian infusion/injection of platelet-rich plasma in infertile women undergoing assisted reproductive technology cycles.

Search methods: We searched the Cochrane Gynaecology and Fertility Group's Specialised Register, CENTRAL, MEDLINE, Embase, and the Epistemonikos database in January 2023. We also searched the reference lists of relevant articles and contacted the trial authors and experts in the field for any additional trials.

Selection criteria: We included randomized controlled trials (RCTs) that evaluated the application of PRP in the uterine cavity, ovaries, or both versus no intervention, placebo, or any other intervention (either mechanical or pharmacological) in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles.

Data collection and analysis: We followed standard methodological procedures recommended by Cochrane, including use of the updated risk of bias tool (RoB 2). The primary outcomes were live birth (or ongoing pregnancy) and miscarriage. The secondary outcomes were clinical pregnancy, complications of the procedure, multiple pregnancy, ectopic pregnancy, fetal growth restriction, preterm delivery, and fetal abnormality. We estimated the average effect of the interventions by fitting a Der Simonian-Laird's random-effects meta-analysis model. We reported pooled odds ratios (ORs) with 95% confidence intervals (CIs). We restricted the primary analyses to trials at low risk of bias for the outcomes and performed sensitivity analyses that included all studies.

Main results: We included 12 parallel-group RCTs that recruited a total of 1069 women. We identified three different comparison groups. Using GRADE, we assessed the certainty of evidence as very low for almost all outcomes. Intrauterine injection/infusion of platelet-rich plasma versus no intervention or placebo Nine studies evaluated intrauterine PRP versus no intervention or placebo. Eight included women with at least two or three previous implantation failures. Only one was assessed at low risk of bias for each outcome. This study provided very low-certainty evidence about the effect of intrauterine PRP injection versus no intervention on live birth (OR 1.10, 95% CI 0.38 to 3.14; 94 women) and miscarriage (OR 0.96, 95% CI 0.13 to 7.09; 94 women). If the likelihood of live birth following no intervention is assumed to be 17%, then the likelihood following intrauterine PRP would be 7% to 40%; and if the risk of miscarriage following no intervention is 4%, then the risk following intrauterine PRP would be 1% to 24%. When we analyzed all studies (regardless of risk of bias), we found very low-certainty evidence about the effect of intrauterine PRP compared with placebo or no intervention on live birth or ongoing pregnancy (OR 2.38, 95% CI 1.16 to 4.86; I² = 54%; 6 studies, 564 women) and miscarriage (OR 1.54, 95% CI 0.59 to 4.01; I² = 0%; 5 studies, 504 women). The study at low risk of bias provided very low-certainty evidence about the effect of intrauterine PRP compared with no intervention on clinical pregnancy (OR 1.55, 95% CI 0.64 to 3.76; 94 women) and ectopic pregnancy (OR 2.94, 95% CI 0.12 to 73.95; 94 women). The synthesis of all studies provided very low-certainty evidence about the effect of intrauterine PRP compared with placebo or no intervention on clinical pregnancy (OR 2.22, 95% CI 1.50 to 3.27; I² = 24%; 9 studies, 824 women), multiple pregnancy (OR 2.68, 95% CI 0.81 to 8.88; I² = 0%; 2 studies, 240 women), and ectopic pregnancy (OR 2.94, 95% CI 0.12 to 73.95; 1 study, 94 women; very low-certainty evidence). Intrauterine infusion of PRP may increase the risk of preterm delivery compared with no intervention (OR 8.02, 95% CI 1.72 to 37.33; 1 study, 120 women; low-certainty evidence). No studies reported pain, infection, allergic reaction, fetal growth restriction, or fetal abnormality. Intrauterine infusion of platelet-rich plasma versus intrauterine infusion of granulocyte colony-stimulating factor Two RCTs evaluated intrauterine PRP versus intrauterine granulocyte colony-stimulating factor (G-CSF); both included women with thin endometrium, and neither was judged at low risk of bias for any outcome. We are uncertain about the effect of intrauterine PRP compared with intrauterine G-CSF on live birth (OR 0.88, 95% CI 0.43 to 1.81; 1 study, 132 women; very low-certainty evidence), miscarriage (OR 1.94, 95% CI 0.63 to 5.96; 1 study, 132 women; very low-certainty evidence), and clinical pregnancy (OR 1.24, 95% CI 0.66 to 2.35; 2 studies, 172 women; very low-certainty evidence). Neither study reported adverse outcomes other than miscarriage. Intraovarian injection of platelet-rich plasma versus no intervention One RCT evaluated PRP injection into both ovaries versus no intervention; it was judged at high risk of bias for the two outcomes it reported. We are uncertain about the effect of intraovarian PRP injection compared with no intervention on ongoing pregnancy (OR 1.09, 95% CI 0.33 to 3.63; 73 women; very low-certainty evidence) and clinical pregnancy (OR 0.90, 95% CI 0.31 to 2.60; 73 women; very low-certainty evidence). The study examined no safety outcomes.

Authors' conclusions: We are uncertain about the effect of intrauterine or intraovarian administration of PRP on outcomes of assisted reproduction technology in infertile women. The pooled results should be interpreted with caution. Only one of the 12 included studies was judged at low risk of bias. Other limitations of the included trials were failure to report live birth, poor reporting of methods, lack of prospective protocol registration, low precision due to the small number of enrolled participants, indirectness due to the specific subpopulations and settings studied, and insufficient or absent safety data.

PubMed Disclaimer

Conflict of interest statement

MP has received grants from the World Health Organization (WHO Reg. Nos. 2021/1110248 & 2022/1270903‐0) outside the submitted work. DV and CSS have no conflicts of interest to disclose.

Figures

1
1
PRISMA flow diagram illustrating the study selection process.
2
2
Risk of bias summary.
3
3
Risk of bias graph.
4
4
Comparison 1: Endometrial injection of platelet‐rich plasma (PRP) versus no intervention or placebo; Outcome 1: Live birth (or ongoing pregnancy) – low risk of bias.
5
5
Comparison 1: Endometrial injection of platelet‐rich plasma (PRP) versus no intervention or placebo; Outcome 2: Live birth (or ongoing pregnancy) – all studies.
6
6
Comparison 1: Endometrial injection of platelet‐rich plasma (PRP) versus no intervention or placebo; Outcome 5: Miscarriage – low risk of bias.
7
7
Comparison 1: Endometrial injection of platelet‐rich plasma (PRP) versus no intervention or placebo; Outcome 6: Miscarriage – all studies.
8
8
Comparison 1: Endometrial injection of platelet‐rich plasma (PRP) versus no intervention or placebo; Outcome 9: Clinical pregnancy – low risk of bias.
9
9
Comparison 1: Endometrial injection of platelet‐rich plasma (PRP) versus no intervention or placebo; Outcome 10: Clinical pregnancy – all studies.
10
10
Comparison 2: Endometrial injection of platelet‐rich plasma (PRP) versus endometrial injection of granulocyte colony‐stimulating factor (G‐CSF); Outcome 1: Live birth.
11
11
Comparison 2: Endometrial injection of platelet‐rich plasma (PRP) versus endometrial injection of granulocyte colony‐stimulating factor (G‐CSF); Outcome 3: Miscarriage.
12
12
Comparison 2: Endometrial injection of platelet‐rich plasma (PRP) versus endometrial injection of granulocyte colony‐stimulating factor (G‐CSF); Outcome 6: Clinical pregnancy.
13
13
Comparison 3: Ovarian injection of platelet‐rich plasma (PRP) versus no intervention; Outcome 1: Ongoing pregnancy.
14
14
Comparison 3: Ovarian injection of platelet‐rich plasma (PRP) versus no intervention; Outcome 3: Clinical pregnancy.
1.1
1.1. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 1: Live birth (or ongoing pregnancy) – low risk of bias
1.2
1.2. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 2: Live birth (or ongoing pregnancy) – all studies
1.3
1.3. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 3: Live birth (or ongoing pregnancy) – sensitivity analysis (risk ratio)
1.4
1.4. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 4: Live birth (or ongoing pregnancy) – sensitivity analysis (live birth only)
1.5
1.5. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 5: Miscarriage – low risk of bias
1.6
1.6. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 6: Miscarriage – all studies
1.7
1.7. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 7: Miscarriage – sensitivity analysis (risk ratio)
1.8
1.8. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 8: Miscarriage – sensitivity analysis (per clinical pregnancy)
1.9
1.9. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 9: Clinical pregnancy – low risk of bias
1.10
1.10. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 10: Clinical pregnancy – all studies
1.11
1.11. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 11: Clinical pregnancy – sensitivity analysis (risk ratio)
1.12
1.12. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 12: Clinical pregnancy – sensitivity analysis (full text only)
1.13
1.13. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 13: Multiple pregnancy – all studies
1.14
1.14. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 14: Multiple pregnancy – sensitivity analysis (risk ratio)
1.15
1.15. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 15: Ectopic pregnancy – low risk of bias
1.16
1.16. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 16: Ectopic pregnancy – sensitivity analysis (risk ratio)
1.17
1.17. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 17: Preterm delivery
1.18
1.18. Analysis
Comparison 1: Intrauterine infusion/injection of platelet‐rich plasma (PRP) versus no intervention or placebo, Outcome 18: Preterm delivery – sensitivity analysis (risk ratio)
2.1
2.1. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 1: Live birth
2.2
2.2. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 2: Live birth – sensitivity analysis (risk ratio)
2.3
2.3. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 3: Miscarriage
2.4
2.4. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 4: Miscarriage – sensitivity analysis (risk ratio)
2.5
2.5. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 5: Miscarriage – sensitivity analysis (per clinical pregnancy)
2.6
2.6. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 6: Clinical pregnancy
2.7
2.7. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 7: Clinical pregnancy – sensitivity analysis (risk ratio)
2.8
2.8. Analysis
Comparison 2: Intrauterine infusion of platelet‐rich plasma (PRP) versus intrauterine infusion of granulocyte colony‐stimulating factor (G‐CSF), Outcome 8: Clinical pregnancy – sensitivity analysis (full text only)
3.1
3.1. Analysis
Comparison 3: Intraovarian injection of platelet‐rich plasma (PRP) versus no intervention, Outcome 1: Ongoing pregnancy
3.2
3.2. Analysis
Comparison 3: Intraovarian injection of platelet‐rich plasma (PRP) versus no intervention, Outcome 2: Ongoing pregnancy – sensitivity analysis (risk ratio)
3.3
3.3. Analysis
Comparison 3: Intraovarian injection of platelet‐rich plasma (PRP) versus no intervention, Outcome 3: Clinical pregnancy
3.4
3.4. Analysis
Comparison 3: Intraovarian injection of platelet‐rich plasma (PRP) versus no intervention, Outcome 4: Clinical pregnancy – sensitivity analysis (risk ratio)
See this image and copyright information in PMC

Update of

  • doi: 10.1002/14651858.CD013875

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

References to studies included in this review

Alhalabi 2019 {published data only}
    1. Alhalabi M, Alsamawi S, Deroubi H, Taha A, Doghouz R, Alkhatib A. Autologous intrauterine platelet-rich plasma instillation for recurrent implantation failure: a pilot study. Human Reproduction 2019;34:i334-5.
Allahveisi 2020 {published data only}
    1. Allahveisi A, Seyedoshohadaei F, Rezaei M, Bazrafshan N, Rahimi K. The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation. Heliyon 2020;6(3):e03577. - PMC - PubMed
Bakhsh 2022 {published data only}
    1. Bakhsh AS, Maleki N, Sadeghi MR, SadeghiTabar A, Tavakoli M, Zafardoust S, et al. Effects of autologous platelet-rich plasma in women with repeated implantation failure undergoing assisted reproduction. JBRA Assisted Reproduction 2022;26(1):84-7. - PMC - PubMed
Baybordi 2022 {published data only}
    1. Baybordi E, Mohseni J, Mosapour P. The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: A randomized controlled trial. International Journal of Reproductive BioMedicine 2022;20(9):753-60. - PMC - PubMed
    1. IRCT2017061434525N. Effect of autologous platelet-rich plasma on improving pregnancy outcomes in repeated implantation failure: a randomized controlled trial. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2017061434525N1 (first received 7 October 2017).
Ershadi 2022 {published data only}
    1. Ershadi S, Noori N, Dashipoor A, Ghasemi M, Shamsa N. Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle. Journal of Family Medicine and Primary Care 2022;11(5):2162-6. - PMC - PubMed
Godha 2019 {published data only}
    1. Godha Z, Nayar KD, Gupta S, Singh S, Gupta M, Kant G, et al. Randomized controlled trial of intrauterine infusion of autologous platelet rich plasma (PRP) versus granulocyte colony stimulating factor (G-CSF) in thin endometrium in frozen embryo transfer. Human Reproduction 2019;34(Suppl 1):i277.
Herlihy 2022 {published data only}
    1. Herlihy N, Cakiroglu Y, Whitehead CV, Klimczak AM, Scott RT, Tiras B, Seli E. The effect of intra-ovarian injection of platelet rich plasma on in vitro fertilization outcomes in young women with poor ovarian response: results from the PROVA (PRP for ovarian activation) trial. Fertility and Sterility 2022;118(4):e320.
Obidniak 2017 {published data only}
    1. Obidniak D, Gzgzyan A, Feoktistov A, Niauri D. Randomized controlled trial evaluating efficacy of autologous platelet-rich plasma therapy for patients with recurrent implantation failure. Fertility and Sterility 2017;108(3):e370.
Safdarian 2022 {published data only}
    1. Safdarian L, Aleyasin A, Aghahoseini M, Lak P, Mosa SH, Sarvi F, et al. Efficacy of the intrauterine infusion of platelet-rich plasma on pregnancy outcomes in patients with repeated implantation failure: a randomized control trial. International Journal of Women's Health and Reproduction Sciences 2022;10(1):38-44.
Selvaraj 2019 {published data only}
    1. Selvaraj P, Selvaraj K, Chandrasekar H, Sairam L. Comparing the effectiveness of intrauterine infusion of platelet-rich plasma and granulocyte-colony-stimulating factor in frozen embryo transfer cycles. The Onco Fertility Journal 2019;2(2):62.
Zamaniyan 2021 {published data only}
    1. IRCT20160815029374N. Effect of PRP on pregnancy. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20160815029374N2 (first received 16 January 2018).
    1. IRCT20160815029374N. PRP in infertility. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20160815029374N5 (first received 11 May 2019).
    1. Zamaniyan M, Peyvandi S, Heidaryan Gorji H, Moradi S, Jamal J, Aghmashhadi FYP, et al. Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial. Gynecological Endocrinology 2021;37(2):141-5. - PubMed
Zargar 2021 {published data only}
    1. IRCT20180102038182N. Platelet derived growth factor and IVF Failure. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20180102038182N1 (first received 21 January 2018).
    1. Zargar M, Pazhouhanfar R, Najafian M, Choghakabodi PM. Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: A prospective randomized study. Clinical and Experimental Obstetrics and Gynecology 2021;48(1):180-5.

References to studies excluded from this review

Abduljabbar 2022 {published data only}
    1. Abduljabbar HS, Hashim H, Abduljabar HH, Elnaeim AA, Abduljabar NH. The effect of autologous platelet-rich plasma treatment on in vitro fertilization/intracytoplasmic sperm injection and its impact on the endometrium and clinical pregnancy rate. Cureus 2022;14(8):e27913. - PMC - PubMed
Aflatoonian 2021 {published data only}
    1. Aflatoonian A, Lotfi M, Saeed L, Tabibnejad N. Effects of intraovarian injection of autologous platelet-rich plasma on ovarian rejuvenation in poor responders and women with primary ovarian insufficiency. Reproductive Sciences 2021;28(7):2050-9. - PubMed
Aghajanzadeh 2020 {published data only}
    1. Aghajanzadeh F, Esmaeilzadeh S, Basirat Z, Mahouti T, Heidari FN, Golsorkhtabaramiri M. Using autologous intrauterine platelet-rich plasma to improve the reproductive outcomes of women with recurrent implantation failure. Jornal Brasileiro de Reproducao Assistida 2020;24(1):30-3. - PMC - PubMed
    1. IRCT20180417039338N. Effect of platelet-rich plasma (PRP)on fertility in women. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20180417039338N2 (18 June 2018).
Bach 2021 {published data only}
    1. Bach HA, Vuong VVH, Bach TTC, Nguyen QH, Pham VP, Nguyen TN. Uterine infusion of autologous platelet rich plasma (PRP) before embryo transfer may improve the transfer outcomes in recurrent implantation failure and thin/scarred endometrium patients. Human Reproduction 2021;36:i330-1.
Barad 2020 {published data only}
    1. Barad DH, Albertini DF, Gleicher N. Endocrine effects of intraovarian injection of platelet-rich plasma (PRP) in women with premature ovarian aging. Fertility and Sterility 2020;114(3):e89.
Barad 2021a {published data only}
    1. Barad DH, Benor A, Molinari E, Patrizio P, Gleicher N. A pilot study of oocyte production and endocrine response after intraovarian treatment with platelet-rich plasma (PRP) in infertile women of very advanced age. Fertility and Sterility 2021;116(3):e242.
Barad 2021b {published data only}
    1. Barad D, Darmon SK, Benor A, Gleicher N. Ovarian function following intraovarian injection of autologous platelet rich plasma (APRP) in women with low functional ovarian reserve. Human Reproduction 2021;36:i410.
Cakiroglu 2019a {published data only}
    1. Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Tayyar AT, Scott RT, et al. In women with poor ovarian response, intraovarian injection of autologous platelet rich plasma improves ovarian reserve and IVF outcome parameters. Fertility and Sterility 2019;112(3):e225.
Cakiroglu 2019b {published data only}
    1. Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Tayyar AT, Scott RT, et al. Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcomes in women with premature ovarian insufficiency. Fertility and Sterility 2019;112(3):e72.
Cakiroglu 2020a {published data only}
    1. Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, et al. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Fertility and Sterility 2020;114(3):e458. - PMC - PubMed
Cakiroglu 2020b {published data only}
    1. Cakiroglu Y, Saltik A, Yuceturk A, Karaosmanoglu O, Kopuk SY, Scott RT, et al. Follicular activation by intraovarian injection of autologous platelet rich plasma (PRP) in women with primary ovarian insufficiency (POI): impact on ovarian reserve and IVF outcome. Fertility and Sterility 2020;114(3):e158. - PMC - PubMed
Cakiroglu 2021a {published data only}
    1. Cakiroglu Y, Tohma YA, Yuceturk A, Karaosmanoglu O, Kopuk SY, Utkan Korun ZE, et al. Effects of subendometrial autologous platelet rich plasma injection on endometrium and pregnancy rates in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer. Fertility and Sterility 2021;116(3):e103. - PMC - PubMed
Cakiroglu 2021b {published data only}
    1. Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk SY, Utkan Korun ZE, Scott RT, et al. IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Fertility and Sterility 2021;116(3):e28-9. - PMC - PubMed
Cakiroglu 2022a {published data only}
    1. Cakiroglu Y, Yuceturk A, Karaosmanoglu O, Kopuk Sule Y, Korun ZEU, Herlihy N, et al. Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Aging 2022;14(6):2513-23. - PMC - PubMed
Cakiroglu 2022b {published data only}
    1. Cakiroglu Y, Tohma YA, Yuceturk A, Karaosmanoglu O, Kopuk SY, Utkan Korun ZE, et al. Subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer. Fertility and Sterility 2022;118(4):e170. - PMC - PubMed
Chang 2017 {published data only}
    1. Chang Y, Li J, Li X, Yang X, Liang X. Platelet-rich plasma administration has benefit for infertile women with thin endometrium in frozen blastocyst-stage embryos transfer program. Fertility and Sterility 2017;108(3):e77.
Chang 2019 {published data only}
    1. Chang Y, Li J, Wei LN, Pang J, Chen J, Liang X. Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium. Medicine (United States) 2019;98(3):e14062. - PMC - PubMed
ChiCTR2000033023 {unpublished data only}
    1. ChiCTR2000033023. The effect of platelet rich plasma (PRP) intrauterine infusion on the outcome of IVF-ET in patients with thin endometrium and repeated implantation failure: a prospective, randomized, single center parallel controlled trial. trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2000033023 (first received 18 May 2020).
CTRI/2022/05/042399 {unpublished data only}
    1. CTRI/2022/05/042399. Role of platelet rich plasma in infertile females with thin endometrium. trialsearch.who.int/Trial2.aspx?TrialID=CTRI/2022/05/042399 (first received 6 May 2022).
Dogra 2020 {published data only}
    1. Dogra Y, Singh N. Autologous platelet-rich plasma optimizes endometrial thickness in women with refractory thin endometrium of varied aetiology during fresh and frozen-thawed embryo transfer cycles. Human Reproduction 2020;35:i276. - PMC - PubMed
Dogra 2022 {published data only}
    1. Dogra Y, Singh N, Vanamail P. Autologous platelet-rich plasma optimizes endometrial thickness and pregnancy outcomes in women with refractory thin endometrium of varied aetiology during fresh and frozen-thawed embryo transfer cycles. Jornal Brasileiro de Reproducao Assistida 2022;26(1):13-21. - PMC - PubMed
Dzhincharadze 2021 {published data only}
    1. Dzhincharadze LG, Abubakirov AN, Mishieva NG, Bakuridze EM, Bystrykh OA. Effectiveness of intrauterine administration of autologous platelet-rich plasma to prepare 'thin' endometrium for the defrosted embryo transfer program. Akusherstvo i ginekologiya (Russian Federation) 2021;2:90-5.
Dzhincharadze 2022 {published data only}
    1. Dzhincharadze L, Abubakirov A, Martazanova B, Korolkova A, Mikhaylova N, Fedorova T, et al. Granulocyte colony-stimulating factor and platelet-rich plasma improve pregnancy outcomes in patients with thin endometrium and recurrent implantation failure (RIF) in frozen embryo transfer cycles (FET). Human Reproduction 2022;37:i359-60.
Efendieva 2020 {published data only}
    1. Efendieva ZN, Apolikhina IA, Kalinina EA, Fyodorova TA, Belousov DM, Fathudinov TK. Autologous platelet-rich plasma injection into the endometrium in patients with uterine factor infertility. Fertility and Sterility 2020;114(3):e166.
Feskov 2020 {published data only}
    1. Feskov O, Zhylkova Y, Feskova A, Blazhko O, Yegunkova O. Clinical applications of platelet-rich plasma in poor endometrium patients in IVF practice. Human Reproduction 2020;35:i302.
Ghasemi 2020 {published data only}
    1. Ghasemi M. Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle. International Journal of Gynecological Cancer 2020;30:A48. - PMC - PubMed
Ibrahim Rajeh 2020 {published data only}
    1. Ibrahim Rageh KA, Barakat A, Mohamed A. PRP in recurrent implantation failure, hope or hype? A Prospective randomized controlled study. Human Reproduction 2020;35:i422.
IRCT20151123025202N {unpublished data only}
    1. IRCT20151123025202N. Assessment addition of autologous platelet-rich plasma in premature ovarian failure effect rejuvenalization [Effect of autologous platelet-rich plasma on ovarian rejuvenalization]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20151123025202N2 (first received 10 November 2019).
IRCT201703079014N {unpublished data only}
    1. IRCT201703079014N. Effects of platelet-rich plasma versus Hams F10 on the ovarian stimulation outcome in infertile women with poor ovarian response [Effects of platelet-rich plasma versus Hams F10 on the ovarian stimulation outcome in infertile women with poor ovarian response: a single blind randomized clinical trial]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT201703079014N150 (first received 8 March 2017).
IRCT2017073034422N {unpublished data only}
    1. IRCT2017073034422N. Effects of autologous platelet- rich plasma on ICSI outcomes and pregnancy rate in frozen embryo transfer cycles in repeated implantation failure patients. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2017073034422N2 (first received 16 October 2017).
Jackman 2020 {published data only}
    1. Jackman JM, Ali-Bynom S, Amberg A, Zhang J, Lipkin L, Olcha M, et al. Platelet rich plasma (PRP) can improve pregnancy outcome in patients with recurrent implantation failure (RIF and thin endometrial lining. Fertility and Sterility 2020;114(3):e333.
JPRN‐UMIN000030493 {unpublished data only}
    1. JPRN-UMIN000030493. Clinical study of infertility treatment using platelet rich plasma (PRP) to endometrium [Clinical study of infertility treatment using platelet rich plasma (PRP) to endometrium. - clinical study of infertility treatment using platelet rich plasma (PRP) to endometrium]. trialsearch.who.int/Trial2.aspx?TrialID=JPRN-UMIN000030493 (first received 25 December 2017).
Katakdhond 2019 {published data only}
    1. Katakdhond MS, Deshmukh SD, Khandeparkar SS, Naik NJ, Sanap M, Naik G, et al. Women with previous failed IVF benefit from intrauterine instillation of platelet rich plasma. Fertility and Sterility 2019;112(3):e185.
Kim 2019 {published data only}
    1. Kim JH, Kim E, Kwon H, Choi DH. Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen embryo transfer cycle. Human Reproduction 2019;34:i314-5. - PMC - PubMed
Kim 2022 {published data only}
    1. KCT0003375. A study about treatment of endometrium using autologous platelet rich plasma in patient suffering repeated implantation failure [A double-blind randomized control trial of autologous platelet-rich plasma in treatment of endometrium in repeated implantation failure patients]. trialsearch.who.int/Trial2.aspx?TrialID=KCT0003375 (first received 25 November 2018).
    1. Kim J, Yoon H, Ko J, Shin SY, Park C, Choi D, et al. Effects of autologous platelet-rich plasma in women with POI and POR. Fertility and Sterility 2022;118(4):e319.
Liu 2021 {published data only}
    1. Liu C, Fang J, Hao C, Xu Y. Platelet-rich plasma intrauterine perfusion combined with hysteroscopic endometrial mechanical stimulation: a new choice for treatment of thin endometrium. Fertility and Sterility 2021;116(3):e315.
Lopez 2019 {published data only}
    1. Lopez EG, Bernardo LG, Fernadez FG. Improvement of endometrial receptivity through the use of autologous platelet-derived microparticles. Fertility and Sterility 2019;112(3):e331-2.
Majiyd 2020 {published data only}
    1. Majiyd NA, Thunga C, Ashraf M, Singh S, Basheer R, Ashraf R, Jayaprakasan K. A comparative evaluation of novel sub-endometrial and intrauterine platelet rich plasma treatment for women with recurrent implantation failure (RIF). Fertility and Sterility 2020;114(3):e285. - PubMed
Molina 2018 {published data only}
    1. Molina AM, Sanchez J, Sanchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. Jornal Brasileiro de Reproducao Assistida 2018;22(1):42-8. - PMC - PubMed
Nagireddy 2019 {published data only}
    1. Nagireddy S, Reddy NS, Pandurangi MD, Vembu R, Manjula DG, Srinivasan SN, et al. Autologous PRP for the management of thin endometrium in frozen embryo transfer cycles: would it improve the outcome? Fertility and Sterility 2019;112(3):e418-9.
NCT03734042 {unpublished data only}
    1. NCT03734042. PRP intrauterine infusion in thawed embryo cycles [Intrauterine infusion of platelet-rich plasma infusion before thawed embryo transfer in repeated implantation failure: a randomized controlled study]. clinicaltrials.gov/study/NCT03734042 (first received 6 November 2018).
NCT03937661 {unpublished data only}
    1. NCT03937661. Ovarian platelet rich plasma treatment for poor responders [Investigating improvement of ovarian function following autologous PRP intra-ovarian infusion in poor responders]. clinicaltrials.gov/show/NCT03937661 (first received 23 April 2019).
NCT03945812 {unpublished data only}
    1. NCT03945812. Granulocyte colony stimulating factor versus platelet rich plasma and outcomes of frozen embryo transfer [The impact of using granulocyte colony stimulating factor (G-CSF) versus platelet rich plasma (PRP) on the outcomes of frozen embryo transfer; randomized controlled study]. clinicaltrials.gov/show/NCT03945812 (first received 8 May 2019).
NCT04240860 {unpublished data only}
    1. NCT04240860. Autologous intrauterine platelet-rich plasma instillation and endometrial scratching for thinned endometrium [Randomized clinical trial between autologous intrauterine platelet-rich plasma instillation and three snip hysteroscopic endometrial scratching for thinned endometrium]. clinicaltrials.gov/show/NCT04240860 (first received 13 September 2019).
NCT04354363 {unpublished data only}
    1. NCT04354363. PRP in intracytoplasmic sperm injection [Role of PRP in intracytoplasmic sperm injection in infertile women]. clinicaltrials.gov/show/NCT04354363 (first received 17 April 2020).
NCT04411212 {unpublished data only}
    1. NCT04411212. G-CSF and PRP in patients with recurrent implantation failure [Granulocyte colony-stimulating factor and platelet-rich plasma group in patients with recurrent implantation failure]. clinicaltrials.gov/show/NCT04411212 (first received 27 May 2020).
NCT04922398 {unpublished data only}
    1. NCT04922398. Ovarian injection of PRP (platelet-rich plasma) vs normal saline in premature ovarian insufficiency [Ovarian injection of PRP (platelet-rich plasma) vs normal saline in premature ovarian insufficiency: a randomized controlled trial]. clinicaltrials.gov/show/NCT04922398 (first received 19 May 2021).
Noushin 2021 {published data only}
    1. Noushin MA, Ashraf M, Thunga C, Singh S, Basheer R, Ashraf R, et al. A comparative evaluation of subendometrial and intrauterine platelet-rich plasma treatment for women with recurrent implantation failure. F&S Science 2021;2(3):295-302. - PubMed
Parvanov 2020 {published data only}
    1. Parvanov D, Ganeva R, Vidolova N, Nikolova K, Vasileva M, Stoykov I, et al. Ovarian autologous platelet-rich plasma (PRP) treatment improves oocyte and embryo quality in women with poor ovarian response. Fertility and Sterility 2020;114(3):e452-3.
Patel 2022 {published data only}
    1. Patel G, Singh N, Malhotra N, Mahey R, Saini M. Intra-ovarian platelet-rich plasma instillation improves IVF outcomes in women with diminished ovarian-reserve. BJOG: An International Journal of Obstetrics and Gynaecology 2022;129:186-7.
Singh 2020 {published data only}
    1. Singh S, Ashraf N, Basheer R, Ashraf M. Use of intraovarian platelet rich plasma does not increase the ovarian reserve markers, ovarian response or IVF outcome in Bologna poor responders. Human Reproduction 2020;35:i37-8.
Stojkovska 2019 {published data only}
    1. Stojkovska S, Dimitrov G, Stamenkovska N, Hadzi-Lega M, Petanovski Z. Live birth rates in poor responders' group after previous treatment with autologous platelet-rich plasma and low dose ovarian stimulation compared with poor responders used only low dose ovarian stimulation before in vitro fertilization. Open Access Macedonian Journal of Medical Sciences 2019;7(19):3184-8. - PMC - PubMed

References to studies awaiting assessment

Eftekhar 2018 {published data only}
    1. Eftekhar M, Neghab N, Naghshineh E, Khani P. Corrigendum to "Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial" [Taiwan J Obstet Gynecol 57 (2018) 810-813]. Taiwanese Journal of Obstetrics and Gynecology 2021;60(5):973. [DOI: 10.1016/j.tjog.2021.08.003] - DOI - PubMed
    1. Eftekhar Maryam, Neghab Nosrat, Naghshineh Elham, Khani Parisa. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwanese Journal of Obstetrics & Gynecology 2018;57(6):810-3. - PubMed
    1. IRCT2016090328950N. Evaluation of intrauterine infusion of autologous platelet rich plasma (PRP) on in vitro fertilization (IVF) [Clinical trial of pregnancy outcome in women with thin endometrium after intrauterine infusion of autologous platelet rich plasma (PRP) in comparison with women with thin endometrium without intervention undergoing frozen thawed cycles]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2016090328950N2 (first received 10 January 2017).
    1. IRCT2016090728950N. Intrauterine infusion of autologous platelet rich plasma (PRP) on women with repeated frozen thawed cycles failure [Clinical trial of comparison of pregnancy outcome in women with history of repeated implantation failure after intrauterine infusion of autologous platelet rich plasma (PRP) and women without intervention undergoing frozen thawed cycles]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2016090728950N3 (first received 22 September 2016).
    1. Neghab N, Eftekhar M, Naghshineh E, Khani P. Pregnancy outcome in women with thin endometrium undergoing frozen-thawed cycles after intrauterine infusion of autologous platelet-rich plasma (PRP). International Journal of Reproductive BioMedicine 2017;15(4):56-7.
Nazari 2019b {published data only}
    1. IRCT20160722029027N. Effect of platelet rich plasma (PRP) improving pregnancy outcome [Effect of platelet rich plasma (PRP) on improving pregnancy outcome in recurrent pregnancy loss patients a randomized clinical trial pilot study]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20160722029027N9 (first received 4 December 2019).
    1. IRCT2016072229027N. Effects of platelet rich plasma on frozen embryo transfer process [Effects of autologous platelet rich plasma on endometrial growth and implantation in intracytoplasmic sperm injection cycles: clinical trial]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2016072229027N1 (first received 5 September 2016).
    1. Nazari L, Salehpour S, Hosseini MS, Hashemi Moghanjoughi P. The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial. Human fertility (Cambridge, England) 2020;23(3):209-13. - PubMed
Nazari 2019c {published data only}
    1. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Azargashb E. Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT. International Journal of Reproductive Biomedicine 2019;17(6):443-8. - PMC - PubMed
Nazari 2022a {published data only}
    1. Nazari L, Salehpour S, Hosseini S, Hashemi T, Borumandnia N, Azizi E. Effect of autologous platelet-rich plasma for treatment of recurrent pregnancy loss: a randomized controlled trial. Obstetrics & Gynecology Science 2022;65(3):266-72. - PMC - PubMed
Nazari 2022b {published data only}
    1. IRCT20160722029027N. Effect of platelet rich plasma (PRP) improving pregnancy outcome [Effect of platelet rich plasma (PRP) on improving pregnancy outcome in recurrent pregnancy loss patients a randomized clinical trial pilot study]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20160722029027N9 (first received 4 December 2019).
    1. IRCT2016072229027N. Effects of platelet rich plasma on frozen embryo transfer process [Effects of autologous platelet rich plasma on endometrial growth and implantation in intracytoplasmic sperm injection cycles: clinical trial]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2016072229027N1 (first received 5 September 2016).
    1. Nazari L, Salehpour S, Hosseini S, Sheibani S, Hosseinirad H. The effects of autologous platelet-rich plasma on pregnancy outcomes in repeated implantation failure patients undergoing frozen embryo transfer: a randomized controlled trial. Reproductive Sciences (Thousand Oaks, Calif.) 2022;29(3):993-1000. - PubMed
Neghab 2017 {published data only}
    1. Neghab N, Eftekhar M, Naghshineh E, Khani P. Pregnancy outcomes in women with history of repeated implantation failure after intrauterine infusion of autologous platelet-rich plasma (PRP) in frozen-thawed cycles. International Journal of Reproductive BioMedicine 2017;15(4):22.
Pourkaveh 2022 {published data only}
    1. Pourkaveh B, Pakravesh J, Shabani M, Gachkar L, Nazarian H, Novin MG, et al. Intrauterine platelet rich plasma (PRP) infusion could change the leukemia inhibitory factor (LIF) pattern in the endometrial secretion of women with recurrent implantation failure: a randomized clinical trial. International Journal of Medical Toxicology and Forensic Medicine 2022;12(4):38493.

References to ongoing studies

ACTRN12622000459729 {unpublished data only}
    1. ACTRN12622000459729. I-PRP-FET Trial: intrauterine platelet-rich-plasma infusion prior to frozen embryo transfer in women undergoing in vitro fertilisation (IVF) [Effect of intrauterine platelet-rich-plasma infusion prior to frozen embryo transfer on the chemical and clinical pregnancy rate in women undergoing in vitro fertilisation (IVF): a randomised controlled trial]. trialsearch.who.int/Trial2.aspx?TrialID=ACTRN12622000459729 (first received 23 March 2022).
CTRI/2021/04/032927 {unpublished data only}
    1. CTRI/2021/04/032927. Scope of a specified blood component instillation into the womb for improving pregnancy rate [Scope of PRP for endometrial receptivity-randomized controlled trial - SCOPE trial]. trialsearch.who.int/Trial2.aspx?TrialID=CTRI/2021/04/032927 (first received 19 April 2021).
IRCT20120215009014N230 {unpublished data only}
    1. IRCT20120215009014N230. Effect of infertility treatment with and without addition of autologous platelet-rich plasma in embryo transfer in patients candidate for intra cytoplasmic sperm injection [Effect of infertility treatment with and without addition of autologous platelet-rich plasma in embryo transfer in patients candidate for intra cytoplasmic sperm injection: a randomized clinical trial]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20120215009014N230 (first received 24 August 2018).
IRCT20160722029027N12 {unpublished data only}
    1. IRCT20160722029027N12. Comparison of the effect of intraovarian injection of PRGF and PRP on improving the response and pregnancy outcomes [Comparison of the effect of intraovarian injection of Plasma Rich Growth Factor (PRGF) and Plasma Rich Platelate (PRP) on improving the response and pregnancy outcomes in women undergoing IVF with poor ovarian response]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20160722029027N12 (first received 14 May 2022).
IRCT201608319014N113 {unpublished data only}
    1. IRCT201608319014N113. Effects of platelet-rich plasma versus Hams F10 on the pregnancy outcome in infertile women with recurrent implantation failure [Effects of platelet-rich plasma versus Hams F10 on the pregnancy outcome in infertile women with recurrent implantation failure: a single blind randomized clinical trial]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT201608319014N113 (first received 9 September 2016).
    1. IRCT2017033133179N1. Comparison of intrauterine injection effects of PRP (platelet-rich plasma) and Hams F10 on the pregnancy outcome in recurrent implantation failure of infertile women after transferring unfrozen embryo. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2017033133179N1 (first received 4 August 2017).
IRCT2016102510210N6 {unpublished data only}
    1. IRCT2016102510210N. Effect of platelet-rich plasma(PRP)on fertility in women with thin endometrium [Effect of intrauterine infusion of autologous platelet-rich plasma(PRP)on endometrial thickness and pregnancy rate as secondary endpoint in FET cycles]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2016102510210N6 (first received 30 October 2016).
IRCT2017061034422N1 {unpublished data only}
    1. IRCT2017061034422N. Effects of autologous platelet- rich plasma on pregnancy rate in intra cytoplasmic sperm injection (ICSI) cycles in repeated implantation failure patients [The single blind clinical trial of effects of autologous platelet-rich plasma on pregnancy rate in ICSI cycles in repeated implantation failure patients]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT2017061034422N1 (first received 5 November 2017).
IRCT20180528039878N3 {unpublished data only}
    1. IRCT20180528039878N. Comparison of intrauterine PRP versus G-CSF in RIF patients [Comparison of clinical pregnancy outcome between intrauterine injection of platelet rich plasma (PRP) and granulocyte colony stimulating factor (G-CSF) in patients with more than two failed embryo transfer cycles -clinical trial]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20180528039878N3 (first received 8 May 2021).
IRCT20180619040147N3 {unpublished data only}
    1. IRCT20180619040147N. Evaluation and comparison of the safety and effectiveness of Intra uterine injection of autologous menstrual blood-derived stem cells (MenSCs) and PRP in unfertilized women with thin unfunctional endometrium. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20180619040147N3 (first received 19 May 2020).
IRCT20190503043454N1 {unpublished data only}
    1. IRCT20190503043454N. Efficacy of platelet-rich plasma on embryo implantation [Efficacy of intrauterine infusion of platelet-rich plasma on pregnancy outcome in patients with repeated implantation failure]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20190503043454N1 (first received 6 July 2019).
IRCT20211108052998N1 {unpublished data only}
    1. IRCT20211108052998N. The effect of platelet rich plasma on pregnancy in patients with repeated implantation failure [Comparison of the effectiveness of one time and two times PRP and non-performing PRP in three groups of women with at least two or more pregnancy failures in high-quality embryo transfer who are candidates for embryo freezing in the embryo transfer cycle]. trialsearch.who.int/Trial2.aspx?TrialID=IRCT20211108052998N1 (first received 9 March 2022).
NCT02660294 {unpublished data only}
    1. NCT02660294. Intrauterine autologous PRP infusion compared to HRT for enhancing endometrial thickness in patients undergoing ICSI [Intrauterine autologous platelet -enriched plasma infusion compared to hormonal replacement therapy for enhancing endometrial thickness in patients undergoing ICSI]. clinicaltrials.gov/show/NCT02660294 (first received 16 January 2016).
NCT03166345 {unpublished data only}
    1. NCT03166345. Use of platelet rich plasma (PRP) for improving thin endometrium [Use of platelet rich plasma (PRP) for improving thin endometrium for IVF women]. clinicaltrials.gov/show/NCT03166345 (first received 18 May 2017).
NCT03379649 {unpublished data only}
    1. NCT03379649. Platelet rich plasma for patients with recurrent implantation failure [Platelet rich plasma for patients with recurrent implantation failure: a prospective randomized pilot study]. clinicaltrials.gov/show/NCT03379649 (first received 15 December 2017).
NCT03996837 {unpublished data only}
    1. NCT03996837. Platelet rich plasma and recurrent implantation failure [Evaluation of the application platelet rich plasma in the treatment of patients with recurrent implantation failure in IVF-ICSI & freeze embryo transfer cycles in Royan Institute; a randomized controlled trial]. clinicaltrials.gov/show/NCT03996837 (first received 26 May 2019).
NCT04434495 {unpublished data only}
    1. NCT04434495. Outcome of platelet rich plasma in ICSI Patients, a randomized controlled trial [Outcome of platelet rich plasma injection in ICSI Patients, a randomized controlled trial]. clinicaltrials.gov/show/NCT04434495 (first received 12 June 2020).
NCT04434547 {unpublished data only}
    1. NCT04434547. An RCT on the effect of platelets rich plasma in ICSI patients with recurrent implantation failure [A randomized controlled trial on the effect of adding platelets rich plasma intrauterine on the day of ovum pickup in ICSI patients with recurrent implantation failure]. clinicaltrials.gov/show/NCT04434547 (first received 12 June 2020).
NCT05279560 {unpublished data only}
    1. NCT05279560. Ovarian PRP (platelet rich plasma) injection for follicular activation [The efficacy and safety of intra-ovarian PRP injection within a prospective, single-blinded, placebo-controlled, randomized, clinical superiority trial in subjects with low ovarian reserve/expected poor ovarian response]. clinicaltrials.gov/show/NCT05279560 (first received 16 January 2022).

Additional references

Alves 2018
    1. Alves R, Grimalt R. Review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disorders 2018;4(1):18-24. [DOI: 10.1159/000477353] - DOI - PMC - PubMed
Anitua 2008
    1. Anitua E, Aguirre JJ, Algorta J, Ayerdi E, Cabezas AI, Orive G, et al. Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers. Journal of Biomedical Materials Research 2008;84(2):415-21. [DOI: 10.1002/jbm.b.30886] - DOI - PubMed
Anitua 2015
    1. Anitua E, Muruzabal F, Tayebba A, Riestra A, Perez VL, Merayo-Lloves J, et al. Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies. Acta Ophthalmologica 2015;93(8):e605-14. [DOI: 10.1111/aos.12710] - DOI - PubMed
Bai 2019
    1. Bai SJ, Zeng B, Zhang L, Huang Z. Autologous platelet-rich plasmapheresis in cardiovascular surgery: a narrative review. Journal of Cardiothoracic and Vascular Anesthesia 2019;pii: S1053-0770(19):30768-72. [DOI: 10.1053/j.jvca.2019.07.129] - DOI - PubMed
Borenstein 2008
    1. Borenstein M, Hedges LV, Higgins JP, Rothstein HR. Introduction to Meta-Analysis. Chichester (UK): John Wiley & Sons, 2008. [DOI: 10.1002/9780470743386] - DOI
Bos‐Mikich 2018
    1. Bos-Mikich A, Oliveira R, Frantz N. Platelet-rich plasma therapy and reproductive medicine. Journal of Assisted Reproduction and Genetics 2018;35(5):753-56. [DOI: 10.1007/s10815-018-1159-8] - DOI - PMC - PubMed
Boutron 2020
    1. Boutron I, Page MJ, Higgins JP, Altman DG, Lundh A, Hróbjartsson A. Chapter 7: Considering bias and conflicts of interest among the included studies. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s), Cochrane Handbook for Systematic Reviews of Interventions Version 6.1 (updated September 2020). Cochrane, 2020. Available from training.cochrane.org/handbook/archive/v6.1.
Calhaz‐Jorge 2017
    1. Calhaz-Jorge C, De Geyter C, Kupka MS, De Mouzon J, Erb K, Mocanu E, et al. Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE. Human Reproduction 2017;32(10):1957-73. [DOI: 10.1093/humrep/dex264] - DOI - PubMed
Carless 2011
    1. Carless PA, Rubens FD, Anthony DM, O'Connell D, Henry DA. Platelet-rich-plasmapheresis for minimising perioperative allogeneic blood transfusion. Cochrane Database of Systematic Reviews 2011, Issue 3. Art. No: CD004172. [DOI: 10.1002/14651858.CD004172.pub2] - DOI - PubMed
Carney 2012
    1. Carney SK, Das S, Blake D, Farquhar C, Seif MM, Nelson L. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No: CD001894. [DOI: 10.1002/14651858.CD001894.pub5] - DOI - PMC - PubMed
Cavalcante 2020
    1. Cavalcante MB, Cavalcante CTMB, Sarno M, Barini R. Intrauterine perfusion immunotherapies in recurrent implantation failures: systematic review. American Journal of Reprodauctive Immunology 2020;83(6):e13242. [DOI: 10.1111/aji.13242] - DOI - PubMed
Chang 2015
    1. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. International Journal of Clinical and Experimental Medicine 2015;8(1):1286-90. [PMID: ] - PMC - PubMed
Chang 2019
    1. Chang Y, Li J, Wei L, Pang J, Chen J, Liang X. Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium. Medicine 2019;98:Article e14062. [DOI: 10.1097/MD.0000000000014062] - DOI - PMC - PubMed
Cohn 2015
    1. Cohn CS, Lockhart E. Autologous platelet-rich plasma: evidence for clinical use. Current Opinion in Hematology 2015;22(6):527-32. [DOI: 10.1097/MOH.0000000000000183] - DOI - PubMed
Deng 2023
    1. Deng H, Wang S, Li Z, Xiao L, Ma L. Effect of intrauterine infusion of platelet-rich plasma for women with recurrent implantation failure: a systematic review and meta-analysis. Journal of Obstetrics and Gynaecology 2023;43(1):2144177. [DOI: 10.1080/01443615.2022.2144177] - DOI - PubMed
Dohan 2009
    1. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends in Biotechnology 2009;27(3):158‐67. [DOI: 10.1016/j.tibtech.2008.11.009] - DOI - PubMed
Eftekhar 2018
    1. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwanese Journal of Obstetrics & Gynecology 2018;57(6):810-3. [DOI: 10.1016/j.tjog.2018.10.007] - DOI - PubMed
Farimani 2016
    1. Farimani M, Bahmanzadeh M, Poorolajal J. A new approach using autologous platelet-rich plasma (PRP) to treat infertility and to improve population replacement rate. Journal of Research in Health Sciences 2016;16(3):172-3. [PMID: ] - PMC - PubMed
Farquhar 2018
    1. Farquhar C, Rishworth JR, Brown J, Nelen WL, Marjoribanks J. Assisted reproductive technology: an overview of Cochrane Reviews. Cochrane Database of Systematic Reviews 2018, Issue 8. Art. No: CD010537. [DOI: 10.1002/14651858.CD010537.pub5] - DOI - PMC - PubMed
Filardo 2010
    1. Filardo G, Kon E, Della Villa S, Vincentelli F, Fornasari PM, Marcacci M. Use of platelet-rich plasma for the treatment of refractory jumper's knee. International Orthopaedics 2010;34(6):909-15. [PMID: ] - PMC - PubMed
Gnainsky 2014
    1. Gnainsky Y, Dekel N, Granot I. Implantation: mutual activity of sex steroid hormones and the immune system guarantee the maternal‐embryo interaction. Seminars in Reproductive Medicine 2014;32(5):337‐45. [DOI: 10.1055/s-0034-1376353] - DOI - PubMed
Gnoth 2005
    1. Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Human Reproduction 2005;20(5):1144-7. [DOI: 10.1093/humrep/deh870] - DOI - PubMed
GRADEpro GDT [Computer program]
    1. GRADEpro Guideline Development Tool. McMaster University and Evidence Prime, 2024. Available at gradepro.org.
Griffin 2012
    1. Griffin XL, Wallace D, Parsons N, Costa ML. Platelet rich therapies for long bone healing in adults. Cochrane Database of Systematic Reviews 2012, Issue 7. Art. No: CD009496. [DOI: 10.1002/14651858.CD009496.pub2] - DOI - PMC - PubMed
Guyatt 2011
    1. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. Journal of Clinical Epidemiology 2011;64(4):383-94. [DOI: 10.1016/j.jclinepi.2010.04.026] - DOI - PubMed
Herkiloglu 2022
    1. Herkiloglu. The effects of platelet rich plasma (PRP) and growth hormone (GWH) treatments on telomerase activity and telomere length in patients with diminished ovarian reserve. In: Fertility and Sterility. Conference: 78th Scientific Congress of the American Society for Reproductive Medicine. Anaheim United States. 118 (4 Supplement) (pp e59). 2022.
Higgins 2020a
    1. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.1 (updated September 2020). Cochrane, 2020. Available from training.cochrane.org/handbook/archive/v6.1.
Higgins 2020b
    1. Higgins JP, Savović J, Page MJ, Elbers RG, Sterne JA. Chapter 8: Assessing risk of bias in a randomized trial. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.10 (updated September 2020). Cochrane, 2020. Available from www.training.cochrane.org/handbook/archive/v6.1.
Hu 2019
    1. Hu Z, Qu S, Zhang J, Cao X, Wang P, Huang S, et al. Efficacy and Safety of Platelet-Rich Plasma for Patients with Diabetic Ulcers: A Systematic Review and Meta-analysis. Advances in Wound Care 2019;8(7):298-308. [DOI: 10.1089/wound.2018.0842] - DOI - PMC - PubMed
Hu 2022
    1. Hu Shifu, Jin Zhishan, Tang Qianqian. Effects of intrauterine infusion of autologous platelet-rich plasma in women undergoing treatment with assisted reproductive technology: a meta-analysis of randomized controlled trials. Geburtshilfe und Frauenheilkunde 2022;137:103078. - PMC - PubMed
Intini 2009
    1. Intini G. The use of platelet‐rich plasma in bone reconstruction therapy. Biomaterials 2009;30(28):4956‐66. [PMID: ] - PubMed
Jin 2022
    1. Jin Xin Hang, Li Yang, Li Dan. Intrauterine interventions for women with two or more implantation failures: a systematic review and network meta-analysis. Frontiers in Endocrinology 2022;13:959121. - PMC - PubMed
Kasius 2014
    1. Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta‐analysis. Human Reproduction Update 2014;20(4):530-41. [DOI: 10.1093/humupd/dmu011] - DOI - PubMed
Kim 2019
    1. Kim H, Shin JE, Koo HS, Kwon H, Choi DH, Kim JH. Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen embryo transfer cycle: a pilot study. Frontiers in Endocrinology 2019;10:61. [DOI: 10.3389/fendo.2019.00061] - DOI - PMC - PubMed
Knighton 1988
    1. Knighton DR, Doucette M, Fiegel VD, Ciresi K, Butler E, Austin L. The use of platelet derived wound healing formula in human clinical trials. Progress in Clinical and Biological Research 1988;266:319‐29. [PMID: ] - PubMed
Lang 2018
    1. Lang S, Loibl M, Herrmann M. Platelet-rich plasma in tissue engineering: hype and hope. European Surgical Research 2018;59(3-4):265-75. [DOI: 10.1159/000492415] - DOI - PubMed
Lee 2020
    1. Lee SY, Shin JE, Kwon H, Choi DH, Kim JH. Effect of autologous adipose-derived stromal vascular fraction transplantation on endometrial regeneration in patients of Asherman's syndrome: a pilot study. Reproductive Sciences 2020;27(2):561-8. [DOI: 10.1007/s43032-019-00055-y] - DOI - PubMed
Lefebvre 2011
    1. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from training.cochrane.org/handbook/archive/v5.1.
Lensen 2018
    1. Lensen SF, Wilkinson J, Leijdekkers JA, La Marca A, Mol BW, Marjoribanks J, et al. Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI). Cochrane Database of Systematic Reviews 2018, Issue 2. Art. No: CD012693. [DOI: 10.1002/14651858.CD012693.pub2] - DOI - PMC - PubMed
Liu 2018
    1. Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen–thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Human Reproduction 2018;33(10):1883–8. [DOI: 10.1093/humrep/dey281] - DOI - PMC - PubMed
Liu 2022
    1. Liu K, Cheng H, Guo Y, Liu Y, Li L, Zhang X. Autologous platelet‐rich plasma intrauterine perfusion to improve pregnancy outcomes after implantation failure: a systematic review and meta‐analysis. Journal of Obstetrics and Gynaecology Research 2022;48(12):3137-51. - PubMed
Macklon 2017
    1. Macklon N. Recurrent implantation failure is a pathology with a specific transcriptomic signature. Fertility and Sterility 2017;108(1):9-14. [DOI: 10.1016/j.fertnstert.2017.05.028] - DOI - PubMed
Maleki‐Hajiagha 2020
    1. Maleki-Hajiagha A, Razavi M, Rouholamin S, Rezaeinejad M, Maroufizadeh S, Sepidarkish M. Intrauterine infusion of autologous platelet-rich plasma in women undergoing assisted reproduction: A systematic review and meta-analysis. Journal of Reproductive Immunology 2020;137:103078. [DOI: 10.1016/j.jri.2019.103078] - DOI - PubMed
Man 2001
    1. Man D, Plosker H, Winland-Brown JE. The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plastic and Reconstructive Surgery 2001;107(1):229-37. [DOI: 10.1097/00006534-200101000-00037] - DOI - PubMed
Marques 2015
    1. Marques LF, Stessuk T, Camargo IC, Sabeh Junior N, dos Santos L, Ribeiro-Paes JT. Platelet-rich plasma (PRP): methodological aspects and clinical applications. Platelets 2015;26(2):101-13. [DOI: 10.3109/09537104.2014.881991] - DOI - PubMed
Martinez‐Zapata 2016
    1. Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database of Systematic Reviews 2016, Issue 5. Art. No: CD006899. [DOI: 10.1002/14651858.CD006899.pub3] - DOI - PMC - PubMed
Mehrafza 2019
    1. Mehrafza M, Kabodmehri R, Nikpouri Z, Pourseify G, Raoufi A, Eftekhari A, et al. Comparing the impact of autologous platelet-rich plasma and granulocyte colony stimulating factor on pregnancy outcome in patients with repeated implantation failure. Journal of Reproduction & Infertility 2019;20:35-41. [PMID: ] - PMC - PubMed
Merchan 2019
    1. Merchán WH, Gómez LA, Chasoy ME, Alfonso-Rodríguez CA, Muñoz AL. Platelet-rich plasma, a powerful tool in dermatology. Journal of Tissue Engineering and Regenerative Medicine 2019;13(5):892-01. [DOI: 10.1002/term.2832] - DOI - PubMed
Mohan 2019
    1. Mohan SP, Jaishangar N, Devy S, Narayanan A, Cherian D, Madhavan SS. Platelet-rich plasma and platelet-rich fibrin in periodontal regeneration: a review. Journal of Pharmacy & Bioallied Sciences 2019;11(Suppl 2):S126-30. [DOI: 10.4103/JPBS.JPBS_41_19] - DOI - PMC - PubMed
Moher 2009
    1. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Medicine 2009;6(7):e1000097. [DOI: 10.1371/journal.pmed.1000097] - DOI - PMC - PubMed
Molina 2018
    1. Molina A, Sánchez J, Sánchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assisted Reproduction 2018;22(1):42-8. [DOI: 10.5935/1518-0557.20180009] - DOI - PMC - PubMed
Moraes 2014
    1. Moraes VY, Lenza M, Tamaoki MJ, Faloppa F, Belloti JC. Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No: CD010071. [DOI: 10.1002/14651858.CD010071] - DOI - PMC - PubMed
Motteram 2015
    1. Motteram C, Vollenhoven B, Hope N, Osianlis T, Rombauts LJ. Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study. Reproductive Biomedicine Online 2015;30(4):340-8. [DOI: 10.1016/j.rbmo.2014.12.004] - DOI - PubMed
Munirah 2007
    1. Munirah S, Samsudin OC, Chen HC, Sharifah Salmah SH, Aminuddin BS, Ruszymah BH. Articular cartilage restoration in load‐bearing osteochondral defects by implantation of autologous chondrocyte‐fibrin constructs. Journal of Bone and Joint Surgery 2007;89(8):1099-109. [DOI: 10.1302/0301-620X.89B8.18451] - DOI - PubMed
Nazari 2016
    1. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Ajori L. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: a pilot study. International Journal of Reproductive BioMedicine 2016;14(10):625-8. [PMID: ] - PMC - PubMed
Nazari 2019a
    1. Nazari L, Salehpour S, Hosseini MS, Hashemi Moghanjoughi P. The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial. Human Fertility (Cambridge) 2019;4:1-5. [DOI: 10.1080/14647273.2019.1569268] - DOI - PubMed
Page 2023
    1. Page MJ, Higgins JP, Sterne JAC. Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 6.4 (updated August 2023). Cochrane, 2023. Available from training.cochrane.org/handbook.
Pandian 2010
    1. Pandian Z, McTavish AR, Aucott L, Hamilton MP, Bhattacharya S. Interventions for 'poor responders' to controlled ovarian hyper stimulation (COH) in in‐vitro fertilisation (IVF). Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No: CD004379. [DOI: 10.1002/14651858.CD004379.pub3] - DOI - PubMed
Pantos 2016
    1. Pantos K, Nitsos N, Kokkali G, Vaxevanoglu T, Markomichaki C, Pantou A, et al. Ovarian rejuvenation and folliculogenesis reactivation in peri-menopausal women after autologous platelet-rich plasma treatment. Human Reproduction 2016;31(Suppl 1):i301.
Patrizio 2015
    1. Patrizio P, Vaiarelli A, Levi Setti PE, Tobler KJ, Shoham G, Leong M, et al. How to define, diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics. Reproductive BioMedicine Online 2015;30(6):581-92. [DOI: 10.1016/j.rbmo.2015.03.002] - DOI - PubMed
Pivazyan 2021
    1. Pivazyan L, Avetisyan J, Unanyan A, Ishchenko A. P–309 Effectiveness of intrauterine infusion of platelet-rich plasma (PRP) vs. granulocyte colony-stimulating factor (G-CSF) in women with thin endometrium undergoing assisted reproduction. Human Reproduction 2021;36(Suppl 1):deab130-308.
Polanski 2020
    1. Polanski L, Baumgarten M, Jayaprakasan K. Interventions for women with thin endometrium undergoing assisted reproductive treatment (ART) – a systematic review and meta-analysis. In: Conference proceedings. Vol. 35. Oxford Univ Press Great Clarendon St, Oxford OX26DP, England, 2020:I269.
Redler 2011
    1. Redler LH, Thompson SA, Hsu SH, Ahmad CS, Levine WN. Platelet‐rich plasma therapy: a systematic literature review and evidence for clinical use. Physician and Sports Medicine 2011;39(1):42-51. [PMID: ] - PubMed
RevMan 2023 [Computer program]
    1. Review Manager (RevMan). Version 5.1.0. The Cochrane Collaboration, 2023. Available at revman.cochrane.org.
Robinson 1993
    1. Robinson CJ. Growth factors: therapeutic advances in wound healing. Annals of Medicine 1993;25:535-8. [PMID: ] - PubMed
Sills 2019
    1. Sills ES, Wood SH. Autologous activated platelet-rich plasma injection into adult human ovary tissue: molecular mechanism, analysis, and discussion of reproductive response. Bioscience Reports 2019;39(6):pii: BSR20190805. [DOI: 10.1042/BSR20190805] - DOI - PMC - PubMed
Siristatidis 2014a
    1. Siristatidis C, Vogiatzi P, Bettocchi S, Basios G, Mastorakos G, Vrachnis N. Transvaginal ovarian trauma, poor responders and improvement of success rates in IVF: anecdotal data and a hypothesis. Medical Hypotheses 2014;83(2):227-31. [DOI: 10.1016/j.mehy.2014.04.022] - DOI - PubMed
Siristatidis 2014b
    1. Siristatidis C, Vrachnis N, Vogiatzi P, Chrelias C, Retamar AQ, Bettocchi S, et al. Potential pathophysiological mechanisms of the beneficial role of endometrial injury in in vitro fertilization outcome. Reproductive Sciences 2014;21(8):955-65. [DOI: 10.1177/1933719114525270] - DOI - PubMed
Siristatidis 2018
    1. Siristatidis CS, Sertedaki E, Vaidakis D, Varounis C, Trivella M. Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies. Cochrane Database of Systematic Reviews 2018, Issue 3. Art. No: CD011872. [DOI: 10.1002/14651858.CD011872] - DOI - PMC - PubMed
Spartalis 2015
    1. Spartalis E, Tomos P, Moris D, Athanasiou A, Markakis C, Spartalis MD, et al. Role of platelet-rich plasma in ischemic heart disease: an update on the latest evidence. World Journal of Cardiology 2015;7(10):665-70. [DOI: 10.4330/wjc.v7.i10.665] - DOI - PMC - PubMed
Sterne 2019
    1. Sterne JA, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:4898. - PubMed
Tan 2005
    1. Tan BK, Vandekerckhove P, Kennedy R, Keay SD. Investigation and current management of recurrent IVF treatment failure in the UK. British Journal of Obstetrics and Gynaecology 2005;112(6):773-80. [DOI: 10.1111/j.1471-0528.2005.00523.x.] - DOI - PubMed
Valdes 2017
    1. Valdes CT, Schutt A, Simon C. Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium. Fertility and Sterility 2017;108(1):15-8. [PMID: ] - PubMed
WHO 2023
    1. World Health Organization. Infertility. www.who.int/news-room/fact-sheets/detail/infertility 2023 (accessed March 15, 2024).
Zegers‐Hochschild 2017
    1. Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care. Human Reproduction 2017;32(9):1786-801. [DOI: 10.1016/j.fertnstert.2017.06.005] - DOI - PMC - PubMed

References to other published versions of this review

Vaidakis 2021
    1. Vaidakis D, Sertedaki E, Karageorgiou V, Siristatidis CS. Autologous platelet‐rich plasma for assisted reproduction. Cochrane Database of Systematic Reviews 2021, Issue 2. Art. No: CD013875. [DOI: 10.1002/14651858.CD013875] - DOI - PMC - PubMed

Publication types

LinkOut - more resources