Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jun;119(3):349-369.
doi: 10.1007/s00395-024-01049-x. Epub 2024 Apr 29.

Targeting cardiomyocyte cell cycle regulation in heart failure

Chaonan Zhu  1   2 , Ting Yuan  3   4   5   6 , Jaya Krishnan  7   8   9   10
Affiliations
Review

Targeting cardiomyocyte cell cycle regulation in heart failure

Chaonan Zhu et al. Basic Res Cardiol. 2024 Jun.

Abstract

Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective treatments for cardiac pathologies. While various medications and surgical interventions have been used to improve cardiac function, they are not able to address the extensive loss of functioning cardiomyocytes that occurs during cardiac injury. As a result, there is growing interest in understanding how the cell cycle is regulated and exploring the potential for stimulating cardiomyocyte proliferation as a means of promoting heart regeneration. This review aims to provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure, while also highlighting established and novel therapeutic strategies targeting this area for treatment purposes.

Keywords: Cardiomyocyte proliferation; Cell cycle; Heart failure.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic diagram of physiological and pathological processes during cardiomyocyte cell cycle progression
See this image and copyright information in PMC

References

    1. Abouleisa RRE, Salama ABM, Ou Q, Tang X-L, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Transient cell cycle induction in cardiomyocytes to treat subacute ischemic heart failure. Circulation. 2022;145:1339–1355. doi: 10.1161/CIRCULATIONAHA.121.057641. - DOI - PMC - PubMed
    1. Agah R, Kirshenbaum LA, Abdellatif M, Truong LD, Chakraborty S, Michael LH, Schneider MD. Adenoviral delivery of E2F–1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest. 1997;100:2722–2728. doi: 10.1172/JCI119817. - DOI - PMC - PubMed
    1. Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach O-Y, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E. ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol. 2020;22:1346–1356. doi: 10.1038/s41556-020-00588-4. - DOI - PubMed
    1. Ahuja P, Sdek P, MacLellan WR. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev. 2007;87:521–544. doi: 10.1152/physrev.00032.2006. - DOI - PMC - PubMed
    1. Alam P, Haile B, Arif M, Pandey R, Rokvic M, Nieman M, Maliken BD, Paul A, Wang Y, Sadayappan S, Ahmed RPH, Kanisicak O. Inhibition of senescence-associated genes Rb1 and Meis2 in adult cardiomyocytes results in cell cycle reentry and cardiac repair post-myocardial infarction. JAHA. 2019;8:e012089. doi: 10.1161/JAHA.119.012089. - DOI - PMC - PubMed

Publication types