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. 1985:8:361-5.
doi: 10.1007/978-3-642-69928-3_74.

Increased response of cytochrome P-450 dependent biotransformation reactions in rat liver to repeated administration of inducers

U Kleeberg, M Sommer, W Klinger

Increased response of cytochrome P-450 dependent biotransformation reactions in rat liver to repeated administration of inducers

U Kleeberg et al. Arch Toxicol Suppl. 1985.

Abstract

A single intraperitoneal administration of 3-methylcholanthrene (3MC) or beta-naphthoflavone (BNF) increased aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin 0-deethylase (EROD) activities. Following a second administration of both inducers 3-4 weeks later, the extent of induction was considerably greater. Such a "booster"-phenomenon was also observed with different cytochrome P-450 (P-450)-dependent N-demethylation reactions after repeated phenobarbital (PB) administrations. Again the P-450 content was higher than after a single PB administration.

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