Atropisomeric Foldamers

Abstract

This concept article explores the emerging role of atropisomerism in foldamer chemistry, a field focussed on oligomers that adopt well-defined conformations through non-covalent interactions. Atropisomerism introduces a novel dimension to foldamer design by restricting rotational freedom around single bonds to dictate molecular shape with precision. Despite the prevalence of atropisomeric bonds in organic synthesis, their application within foldamers remains underexplored. Here, we discuss key developments in both backbone and sidechain atropisomerism, and suggest future directions for atropisomeric foldamers in the context of a recent surge in atropselective synthetic methods. We propose that judicious use of atropisomerism may serve as a transformative tool in the construction of shape-defined macromolecules.

Keywords: asymmetric synthesis; atropisomerism; foldamer; macromolecules; oligomers.