Iron chelation
- PMID: 38683929
- Bookshelf ID: NBK603094
Iron chelation
© Thalassaemia International Federation.
Sections
- Aims of iron chelation therapy
- Sources of chelatable (chelateable) iron
- Chemical and pharmacological properties of licensed chelators
- Practical prescribing of individual chelators
- Recommended treatment regimens for DFO monotherapy
- Deferasirox (Exjade®, Asunra®; DFX)
- Combination therapies
- Appendix 1
- Appendix 2
- Appendix 3
- References
References
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- Agarwal M.B., Gupte S.S., Viswanathan C., Vasandani D., et al. Long-term assessment of efficacy and safety of L1, an oral iron chelator, in transfusion dependent thalassaemia: Indian trial. British Journal of Haematology. [Online] 1992;82(2):460–466. doi: 10.1111/j.1365-2141.1992.tb06445.x. Available from: doi: - DOI - PubMed
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- Aldouri M.A., Wonke B., Hoffbrand A.V., Flynn D.M., et al. High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. Acta Haematologica. [Online] 1990;84(3):113–117. doi: 10.1159/000205046. Available from: doi: - DOI - PubMed
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- Anderson L.J., Westwood M.A., Holden S., Davis B., et al. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. British Journal of Haematology. [Online] 2004;127(3):348–355. Available from: doi: https://doi.org/10.1111/j.1365-2141.2004.05202.x. - DOI - PubMed
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- Aydinok Y., Evans P., Terzi A., Cetiner N., et al. Randomised Prospective Evaluation of Iron Balance, Chelation Efficiency, Urine Excretion and NTBI Progression with Deferiprone (DFP) or Deferoxamine (DFO) Monotherapy or with Combined DFP Plus DFO. Blood. [Online] 2005;106(11):2698–2698. doi: 10.1182/blood.V106.11.2698.2698. Available from: doi: - DOI
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- Aydinok Y., Kattamis A., Cappellini M.D., El-Beshlawy A., et al. Deferasirox– Deferoxamine Combination Therapy Reduces Cardiac Iron With Rapid Liver Iron Removal In Patients With Severe Transfusional Iron Overload (HYPERION) Blood. [Online] 2013;122(21):2257–2257. doi: 10.1182/blood.V122.21.2257.2257. Available from: doi: - DOI