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Meta-Analysis
. 2024 Apr 29;24(1):287.
doi: 10.1186/s12887-024-04768-1.

The effect of vitamin D status on the occurrence of Kawasaki Disease: a meta-analysis

Haixiang Zhang  1   2 , Fuyong Jiao  3 , Jiaojiao Wang  1   4 , Cuixiang Xu  5   6 , Kejin Zhang  7   8
Affiliations
Meta-Analysis

The effect of vitamin D status on the occurrence of Kawasaki Disease: a meta-analysis

Haixiang Zhang et al. BMC Pediatr. .

Abstract

Aim: The relationship between vitamin D status and Kawasaki Disease (KD), as well as coronary artery lesion (CAL), has yet to be established.

Methods: A meta-analysis was conducted to assess the correlation between vitamin D status and KD, as well as the impact of vitamin D status on the progression of KD into CAL.

Results: The meta-analysis revealed a consistent and significant association between serum 25(OH)D level and the occurrence KD (studies N = 22; z = -3.51, P < 0.001). Patients with KD had markedly lower levels of vitamin D than healthy controls (SMD: -1.30 ng/mL, 95%CI: -2.05 to -0.55 ng/mL).

Conclusion: The study provided evidence supporting a significant association between lower serum vitamin D levels and the occurrence of KD, particularly within the Chinese population. However, the findings did not suggest a direct impact of vitamin D on the development of CAL in KD patients.

Keywords: 25-hydroxyvitamin D; Coronary artery lesion; Kawasaki disease; Vitamin D.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A literature reviewing for the relationship between vitamin D status and Kawasaki disease
Fig. 2
Fig. 2
The estimated difference of serum 25(OH)D level on KD, grouped by the condition of complications. The difference of serum 25(OH)D level between patients with KD and control group was estimated and pooled through meta-analysis. Each bright gray square represented the effect value of one study. Estimates of overall and subgroups were presented in black prisms. The bright gray band below was the confidence interval of the overall effect value. SMD, standardized mean difference; CI, confidence interval; CAL, KD patients with coronary artery lesion; NCAL, KD patients without CAL
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References

    1. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi. 1967;16(3):178–222. - PubMed
    1. Holman RC, et al. Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics. 2003;112(3 Pt 1):495–501. doi: 10.1542/peds.112.3.495. - DOI - PubMed
    1. Huang GY. Challenges in the diagnosis and treatment of Kawasaki disease. Zhonghua Er Ke Za Zhi. 2022;60(1):3–5. - PubMed
    1. Correction to: Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation, 2019. 140(5):e181–e184. - PubMed
    1. Baker AL, Newburger JW. Cardiology patient pages Kawasaki disease. Circulation. 2008;118(7):e110–e112. doi: 10.1161/CIRCULATIONAHA.107.751404. - DOI - PubMed

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