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. 2024 Apr 1;27(4):183-190.
doi: 10.34172/aim.2024.27.

Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)

Bahar Saberzadeh-Ardestani  1 , Amir Ali Khosravi  1 , Fariborz Mansour-Ghanaei  2 , Homayoon Vahedi  1 , Nadieh Baniasadi  3 , Mohammadreza Seyyedmajidi  4 , Baran Parhizkar  5 , Ahmad Hormati  1 , Sayed Jalalledin Naghshbandi  5 , Somaieh Matin  6   7 , Amir Abbas Hassan Zadeh  8 , Tarang Taghvaei  9 , Mohsen Bahrami  10 , Mandana Rafeey  11 , Mitra Ahadi  12 , Hassan Vossoughinia  12 , Hashem Muosavi  10 , Shahsanam Gheibi  13 , Roya-Sadat Hosseini-Hemmatabadi  14 , Abbas Yazdanbod  15 , Saied Matinkhah  16 , Farshad Sheikh Esmaeili  5 , Hafez Fakheri  9 , Seyed Hamid Moosavy  17 , Iradj Maleki  9 , Siavosh Nasseri-Moghaddam  1 , Bardia Khosravi  1 , Fatemeh Farahmand  18 , Mehri Najafi  19 , Hosein Alimadadi  20 , Masoud Malekzadeh  1 , Amir Anushiravani  1 , Amir Kasaeian  21   22   23 , Sudabeh Alatab  1 , Anahita Sadeghi  1 , Amir Reza Radmard  24 , Shadi Kolahdoozan  1 , Zeynab Rajabi  25 , Ali Reza Sima  1   10
Affiliations

Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC)

Bahar Saberzadeh-Ardestani et al. Arch Iran Med. .

Abstract

Background: Data on the epidemiology of inflammatory bowel disease (IBD) in the Middle East are scarce. We aimed to describe the clinical phenotype, disease course, and medication usage of IBD cases from Iran in the Middle East.

Methods: We conducted a cross-sectional study of registered IBD patients in the Iranian Registry of Crohn's and Colitis (IRCC) from 2017 until 2022. We collected information on demographic characteristics, past medical history, family history, disease extent and location, extra-intestinal manifestations, IBD medications, and activity using the IBD-control-8 questionnaire and the Manitoba IBD index, admissions history, history of colon cancer, and IBD-related surgeries.

Results: In total, 9746 patients with ulcerative colitis (UC) (n=7793), and Crohn's disease (CD) (n=1953) were reported. The UC to CD ratio was 3.99. The median age at diagnosis was 29.2 (IQR: 22.6,37.6) and 27.6 (IQR: 20.6,37.6) for patients with UC and CD, respectively. The male-to-female ratio was 1.28 in CD patients. A positive family history was observed in 17.9% of UC patients. The majority of UC patients had pancolitis (47%). Ileocolonic involvement was the most common type of involvement in CD patients (43.7%), and the prevalence of stricturing behavior was 4.6%. A prevalence of 0.3% was observed for colorectal cancer among patients with UC. Moreover,15.2% of UC patients and 38.4% of CD patients had been treated with anti-tumor necrosis factor (anti-TNF).

Conclusion: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.

Keywords: Clinical phenotype; Disease course; Inflammatory bowel disease.

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Conflict of interest statement

Competing Interests

All the authors declare no conflict of interest.

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