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. 2024 Jun;76(3):1085-1089.
doi: 10.1007/s13304-024-01854-y. Epub 2024 Apr 30.

The Underestimated Impact of Hashimoto Thyroiditis on Thyroid Papillary Carcinoma

Ahmet Tarik Harmantepe  1 , Kayhan Ozdemir  2 , Zulfu Bayhan  3 , Belma Kocer  2
Affiliations

The Underestimated Impact of Hashimoto Thyroiditis on Thyroid Papillary Carcinoma

Ahmet Tarik Harmantepe et al. Updates Surg. 2024 Jun.

Abstract

It is stated that Hashimoto's Thyroiditis (HT) is a risk factor for the development of Papillary Thyroid Cancer (PTC). However, the effect of HT on the coexistence of HT and PTC is still controversial. In this study, our aim is to investigate the effect of the presence of HT on clinicopathological data in patients with PTC. All 356 patients whose pathology was reported as PTC who were operated between 2015 and 2023 were included in the study. PTC patients were divided into 2 groups as those with and without HT. The effect of HT association on clinicopathological features was investigated. In 356 PTC patients, the rate of HT was 31.2%. PTC patients with HT had less multifocality (p < 0.05), more lymph node metastases (LNM) (p < 0.01) compared to PTC patients without HT. The presence of HT did not affect the bilaterality of the tumor, tumor diameter, lymphovascular invasion, or capsule invasion. While multifocality was observed less frequently in PTC patients with HT, lymph node metastasis rates were higher.

Keywords: Hashimoto’s thyroiditis; Lymphocytic infiltration; Papillary thyroid cancer.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

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References

    1. Hu S, Rayman MP. Multiple nutritional factors and the risk of Hashimoto’s thyroiditis. Thyroid. 2017;27(5):597–610. doi: 10.1089/thy.2016.0635. - DOI - PubMed
    1. Fallahi P, Ferrari SM, Ruffilli I, Elia G, Biricotti M, Vita R, et al. The association of other autoimmune diseases in patients with autoimmune thyroiditis: review of the literature and report of a large series of patients. Autoimmun Rev. 2016;15(12):1125–1128. doi: 10.1016/j.autrev.2016.09.009. - DOI - PubMed
    1. Zhang Y, Dai J, Wu T, Yang N, Yin Z. The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol. 2014;140(6):1021–1026. doi: 10.1007/s00432-014-1629-z. - DOI - PMC - PubMed
    1. Liang J, Zeng W, Fang F, Yu T, Zhao Y, Fan X, et al. Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients. Acta Otorhinolaryngol Ital. 2017;37(5):393–400. doi: 10.14639/0392-100X-1709. - DOI - PMC - PubMed
    1. Zhu F, Shen YB, Li FQ, Fang Y, Hu L, Wu YJ. The effects of Hashimoto thyroiditis on lymph node metastases in unifocal and multifocal papillary thyroid carcinoma: a retrospective Chinese Cohort study. Medicine. 2016;95(6):e2674. doi: 10.1097/MD.0000000000002674. - DOI - PMC - PubMed