Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 1;67(2):399-410.
doi: 10.1097/GRF.0000000000000865. Epub 2024 Apr 29.

Antenatal Late Preterm Steroids: The Evolution of the ALPS Trial

Cynthia Gyamfi-Bannerman  1
Affiliations

Antenatal Late Preterm Steroids: The Evolution of the ALPS Trial

Cynthia Gyamfi-Bannerman. Clin Obstet Gynecol. .

Abstract

The Antenatal Late Preterm Steroids (ALPS) trial was designed to address respiratory morbidity common in infants born late preterm. The study was published in April, 2016 and, shortly thereafter, changed clinical practice in obstetrics in the United States. The following chapter describes the ALPS trial study design in detail, including the background leading to the trial, the study outcomes, and the initial findings of the long-term follow-up study. The ALPS story would not be complete without Elizabeth Thom, PhD, who died before her time. Her brilliance largely contributed to the design of the ALPS trial.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. ALPS Primary Outcome, Composite of Need for Respiratory Support
Composite of Need for Respiratory Support, Relative Risk 0.80, 95% CI 0.66-0.97, P=0.02
Figure 2.
Figure 2.. ALPS Main Secondary Outcome, Severe Respiratory Complication
Severe Respiratory Morbidity, Relative Risk 0.66; 95% CI, 0.52 to 0.82; P<0.001
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. JAMA 1995;273(5):413–8. DOI: 10.1001/jama.1995.03520290065031. - DOI - PubMed
    1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75–84. DOI: 10.1016/S0140-6736(08)60074-4. - DOI - PMC - PubMed
    1. Manuck TA. Pharmacogenomics of preterm birth prevention and treatment. BJOG : an international journal of obstetrics and gynaecology 2016;123(3):368–75. DOI: 10.1111/1471-0528.13744. - DOI - PMC - PubMed
    1. Russell RB, Green NS, Steiner CA, et al. Cost of hospitalization for preterm and low birth weight infants in the United States. Pediatrics 2007;120(1):e1–9. DOI: 10.1542/peds.2006-2386. - DOI - PubMed
    1. Ananth CV, Friedman AM, Gyamfi-Bannerman C. Epidemiology of moderate preterm, late preterm and early term delivery. Clinics in perinatology 2013;40(4):601–10. DOI: 10.1016/j.clp.2013.07.001. - DOI - PubMed

Substances