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. 2024 Jun 1;67(2):399-410.
doi: 10.1097/GRF.0000000000000865. Epub 2024 Apr 29.

Antenatal Late Preterm Steroids: The Evolution of the ALPS Trial

Cynthia Gyamfi-Bannerman  1
Affiliations

Antenatal Late Preterm Steroids: The Evolution of the ALPS Trial

Cynthia Gyamfi-Bannerman. Clin Obstet Gynecol. .

Abstract

The Antenatal Late Preterm Steroids (ALPS) trial was designed to address respiratory morbidity common in infants born late preterm. The study was published in April, 2016 and, shortly thereafter, changed clinical practice in obstetrics in the United States. The following chapter describes the ALPS trial study design in detail, including the background leading to the trial, the study outcomes, and the initial findings of the long-term follow-up study. The ALPS story would not be complete without Elizabeth Thom, PhD, who died before her time. Her brilliance largely contributed to the design of the ALPS trial.

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Figures

Figure 1.
Figure 1.. ALPS Primary Outcome, Composite of Need for Respiratory Support
Composite of Need for Respiratory Support, Relative Risk 0.80, 95% CI 0.66-0.97, P=0.02
Figure 2.
Figure 2.. ALPS Main Secondary Outcome, Severe Respiratory Complication
Severe Respiratory Morbidity, Relative Risk 0.66; 95% CI, 0.52 to 0.82; P<0.001
See this image and copyright information in PMC

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