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Editorial
. 2024 Apr 24;15(4):468-471.
doi: 10.5306/wjco.v15.i4.468.

Understanding the role of transmembrane 9 superfamily member 1 in bladder cancer pathogenesis

Venkata Krishna Vamsi Gade  1 , Budhi Singh Yadav  2
Affiliations
Editorial

Understanding the role of transmembrane 9 superfamily member 1 in bladder cancer pathogenesis

Venkata Krishna Vamsi Gade et al. World J Clin Oncol. .

Abstract

In this editorial we comment on the article by Wei et al, published in the recent issue of the World Journal of Clinical Oncology. The authors investigated the role of Transmembrane 9 superfamily member 1 (TM9SF1) protein in bladder cancer (BC) carcinogenesis. Lentiviral vectors were used to achieve silencing or overexpression of TM9SF1 gene in three BC cell lines. These cell lines were then subject to cell counting kit 8, wound-healing assay, transwell assay, and flow cytometry. Proliferation, migration, and invasion of BC cells were increased in cell lines subjected to TM9SF1 overexpression. TM9SF1 silencing inhibited proliferation, migration and invasion of BC cells. The authors conclude that TM9SF1 may be an oncogene in bladder cancer pathogenesis.

Keywords: Lentiviral vectors; Migration; Oncogene; Proliferation; Transmembrane 9 superfamily member 1 gene cell line; Urinary bladder cancer; Wound healing assay.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

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