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. 2024 Apr 10;48(17):7548-7551.
doi: 10.1039/d4nj00859f. eCollection 2024 Apr 29.

A colorimetric approach for monitoring the reduction of platinum(iv) complexes in aqueous solution

Shitong Huang  1 , Jevon W Marsh  1 , Jhanelle R G White  2 , Tracy Q Ha  2 , Sophie A Twigger  3 , Ismael Diez-Perez  2 , Adam C Sedgwick  1   2
Affiliations

A colorimetric approach for monitoring the reduction of platinum(iv) complexes in aqueous solution

Shitong Huang et al. New J Chem. .

Abstract

We report the synthesis of 4-nitrophenyl (4-NP) functionalised Pt(iv) complexes as a colorimetric strategy for monitoring Pt(iv) reduction in aqueous solution. Treatment of each 4-NP functionalised Pt(iv) complex with the biological reductant sodium ascorbate led to a colour change from clear to yellow, which was attributed to the reduction of Pt(iv) to Pt(ii) and simultaneous release of 4-nitroaniline. Trends in reduction profiles and a photocatalysed reduction for each Pt(iv) complex were observed.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Scheme 1
Scheme 1. The general design of the colorimetric strategy developed in this study for monitoring platinum(iv) reduction.
Fig. 1
Fig. 1. Reaction scheme for the synthesis of 4-nitrophenyl functionalised Pt(iv) complexes used in this study (Cis-4NP, Oxali-4NP, Carbo-4NP and Transazide-4NP).
Fig. 2
Fig. 2. (a) Absorption spectra of Cis-4NP (50 μM) in a PBS buffer solution (pH = 7.40, with 1% DMF) containing NaAsc (100 equiv., 5 mM). Measurements were taken over the course of 7 hours. (b) Bar chart of the change in absorption (404 nm/338 nm) of Cis-4NP (50 μM) treated with different reductants NaAsc (100/50/10 equiv., 5/2.5/0.5 mM), l-cys (10 equiv., 0.5 mM) and GSH (10 equiv., 0.5 mM) and measured after 3 hours incubation. (c) and (d) Bar charts of the changes in absorption (404 nm/338 nm) of Oxali-4NP and Carbo-4NP (50 μM) treated with different reductants; NaAsc (100/50/10 equiv., 5/2.5/0.5 mM); l-cys (10 equiv., 0.5 mM) and GSH (10 equiv. 0.5 mM) and measured after 7 hours incubation. Error bars represent SD.
Fig. 3
Fig. 3. (a) Absorption spectra of Transazide-4NP (25 μM) in PBS buffer solution (pH = 7.40, with 1% DMF) under light irradiation from 0–5 hours. (b) Bar chart of the change in absorption (A404 nm/A338 nm) of Cis-4NP with difference concentrations of NaAsc (100/50/10 equiv., 5/2.5/0.5 mM) under light irradiation (3 hours). (c) and (d) Bar chart of the change in absorption (A404nm/A338nm) of Oxali-4NP/Carbo-4NP (50 μM) with difference concentrations of NaAsc (NaAsc (100/50/10 equiv., 5/2.5/0.5 mM) under light irradiation (7 hours)). Error bars represent SD.
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