Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr 22:2024:9990562.
doi: 10.1155/2024/9990562. eCollection 2024.

Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges-A Narrative Review

Muhsen Alnasser  1 , Abdullah Hammad Alshammari  2 , Amna Yusuf Siddiqui  3 , Osama Shujaa Alothmani  3 , Rakhi Issrani  4   5 , Azhar Iqbal  1 , Osama Khattak  1 , Namdeo Prabhu  6
Affiliations
Review

Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges-A Narrative Review

Muhsen Alnasser et al. Scientifica (Cairo). .

Abstract

Background: As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 Statement, the electronic databases looked at were PubMed, Science Direct, Scopus, and Google Scholar, with the keyword search "hard dental tissue regeneration."

Results: Database analysis yielded a total of 476 articles. 222 duplicate articles have been removed in total. Articles that have no connection to the directed regeneration of hard dental tissue were disregarded. The review concluded with the inclusion of four studies that were relevant to our research objective.

Conclusion: Current molecular signaling network investigations and novel viewpoints on cellular heterogeneity have made advancements in understanding of the kinetics of dental hard tissue regeneration possible. Here, we outline the fundamentals of stem hard dental tissue maintenance, regeneration, and repair, as well as recent advancements in the field of hard tissue regeneration. These intriguing findings help establish a framework that will eventually enable basic research findings to be utilized towards oral health-improving medicines.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart of the study selection process.
See this image and copyright information in PMC

References

    1. Olaru M., Sachelarie L., Calin G. Hard dental tissues regeneration—approaches and challenges. Materials . 2021;14(10):p. 2558. doi: 10.3390/ma14102558. - DOI - PMC - PubMed
    1. Mikos A. G., Herring S. W., Ochareon P., et al. Engineering complex tissues. Tissue Engineering . 2006;12(12):3307–3339. doi: 10.1089/ten.2006.12.3307. - DOI - PMC - PubMed
    1. Mao J., Vunjak-Novakovic G., Mikos A., Atala A. Regenerative Medicine: Translational Approaches and Tissue Engineering . Boston, MA, USA: Artech House; 2007.
    1. Cutter C. S., Mehrara B. J. Bone grafts and substitutes. Journal of Long-Term Effects of Medical Implants . 2006;16(3):249–260. doi: 10.1615/jlongtermeffmedimplants.v16.i3.50. - DOI - PubMed
    1. Nap. Selected Health Conditions and Likelihood of Improvement with Treatment . Washington, DC, USA: National Academies Press (US); 2020. National Academies of Sciences E Medicine. Musculoskeletal Disorders. - PubMed