Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr;36(4):610-614.
doi: 10.1016/j.sdentj.2024.02.001. Epub 2024 Feb 7.

Epidemiological and histopathological patterns of malignant salivary gland tumors in the Sudanese population

Yassmin Abdalla Mustafa Mohamed  1 , Hagir A Mahmoud  1   2 , Fatima Abdalmunim AbdElrahman Eltahir  1 , Abeer Hemedan Mohammed Ahmed  1   2 , Yousif Osman Yousif  1   3
Affiliations

Epidemiological and histopathological patterns of malignant salivary gland tumors in the Sudanese population

Yassmin Abdalla Mustafa Mohamed et al. Saudi Dent J. 2024 Apr.

Abstract

Background: Malignant salivary gland tumors are rare. However, their morphological overlap and difficulty to differentiate benign from malignant makes diagnosing such diseases a challenging task. Geographical variation in distribution of these diseases is well documented in the literature. This study aims to review the histological and epidemiological variations of malignant salivary gland tumors in Sudanese patients considering the new WHO 2022 classification.

Methodology: This retrospective study included malignant salivary gland tumours in our lab spanning from the period of 2014 to 2022. Information about clinical data, habits, geographical distribution, pathological diagnosis, duration and sites of tumors were retrieved from our archives. Equivocal cases were checked by a salivary gland expert. Data analysis was performed using IBM SPSS 29.

Results: This study included 107 cases of malignant salivary gland tumours, representing 54 % of the total number of salivary gland tumours in the lab during that period. 47.7 % of the patients in this study were females and 52.3 % were males, the mean age of patients was 50 ± 15.7 years. (30 %) of the patients were from the central region of the country. The most common malignant salivary gland tumor was the Mucoepidermoid carcinoma accounting for 17 %. The palate was found to be the most common site as 38 % of malignant salivary gland tumors occurred in this site.

Conclusion: The study found a high percentage of salivary gland tumours in the Sudan suggesting geographical differentiation.

Keywords: Malignant tumors; Salivary gland; Sudanese.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Distribution of cases according to geographical location.
Fig. 2
Fig. 2
(A) Magnification ×4 H&E stained section shows a monomorphic salivary type carcinoma with prominent nesting and neuroendocrine like features consistent with mucoacinar variant of myoepithelial carcinoma. (B) Magnification ×40 shows a nest of clear to amphophilic cells with lymphocytic infiltrate.
Fig. 3
Fig. 3
Magnification: ×4, H&E stained section of mucinous myoepithelial carcinoma show myoepithelial cells with signet ring morphology and pools of mucin.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Abdulghani, A., n.d. Salivary Gland Tumors in Sudan: a hospital based study from 2004 to 2010.
    1. Al Sarraj Y., Nair S.C., Al Siraj A., AlShayeb M. Characteristics of salivary gland tumours in the United Arab Emirates. Ecancermedicalscience. 2015;9 doi: 10.3332/ecancer.2015.583. - DOI - PMC - PubMed
    1. Ali, Y., 2018. Tumours of Salivary Glands in Sudan.
    1. Alraddadi, T., Aldhahri, S., Alharbi, J., Malas, M., Islam, T., Altuwaijri, A., Al-Qahtani, K., n.d. Predictors for salivary gland cancer recurrence at two tertiary hospitals in Saudi Arabia. Cureus 11, e5288. doi: 10.7759/cureus.5288. - PMC - PubMed
    1. Alsalem, A.A., AlKraidees, M.S., AlKarni, A.F., Yahya, B.J., AlRamyan, R.K., AlSumairi, S.A., AlEssa, M.A., Elkrim, M., 2022. Major salivary glands carcinoma in Saudi Arabia: a 10-year nationwide retrospective study of 571 cases (preprint). In Review. doi: 10.21203/rs.3.rs-2033704/v1. - PMC - PubMed

LinkOut - more resources