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Review
. 2024 May 15;38(9):e23642.
doi: 10.1096/fj.202302665R.

Role of epigenetic regulatory mechanisms in age-related bone homeostasis imbalance

Yunyu Zhong  1 , Xueer Zhou  1 , Zijian Pan  1 , Jiankang Zhang  1 , Jian Pan  1
Affiliations
Review

Role of epigenetic regulatory mechanisms in age-related bone homeostasis imbalance

Yunyu Zhong et al. FASEB J. .

Abstract

Alterations to the human organism that are brought about by aging are comprehensive and detrimental. Of these, an imbalance in bone homeostasis is a major outward manifestation of aging. In older adults, the decreased osteogenic activity of bone marrow mesenchymal stem cells and the inhibition of bone marrow mesenchymal stem cell differentiation lead to decreased bone mass, increased risk of fracture, and impaired bone injury healing. In the past decades, numerous studies have reported the epigenetic alterations that occur during aging, such as decreased core histones, altered DNA methylation patterns, and abnormalities in noncoding RNAs, which ultimately lead to genomic abnormalities and affect the expression of downstream signaling osteoporosis treatment and promoter of fracture healing in older adults. The current review summarizes the impact of epigenetic regulation mechanisms on age-related bone homeostasis imbalance.

Keywords: DNA methylation; age‐related bone loss; bone homeostasis; bone marrow mesenchymal stem cell; histone modification; noncoding RNA.

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References

REFERENCES

    1. Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast‐osteoclast communication and bone homeostasis. Cells. 2020;9(9):2073. doi:10.3390/cells9092073
    1. Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. 2008;3 Suppl 3(Suppl 3):S131‐S139. doi:10.2215/CJN.04151206
    1. Matsuoka K, Park KA, Ito M, Ikeda K, Takeshita S. Osteoclast‐derived complement component 3a stimulates osteoblast differentiation. J Bone Miner Res. 2014;29(7):1522‐1530.
    1. Chen X, Wang Z, Duan N, Zhu G, Schwarz EM, Xie C. Osteoblast‐osteoclast interactions. Connect Tissue Res. 2018;59(2):99‐107. doi:10.1080/03008207.2017.1290085
    1. Park‐Min KH. Epigenetic regulation of bone cells. Connect Tissue Res. 2017;58(1):76‐89. doi:10.1080/03008207.2016.1177037

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