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Editorial
. 2024 May 1;209(9):1062-1064.
doi: 10.1164/rccm.202402-0424ED.

The Controversy Continues: Whether to Perform Plasma Exchange, and with What Dose of Steroids, in the PEXIVAS Trial

Marilyn K Glassberg  1 , Alissa Ali  1 , Gina Gregorini  2
Affiliations
Editorial

The Controversy Continues: Whether to Perform Plasma Exchange, and with What Dose of Steroids, in the PEXIVAS Trial

Marilyn K Glassberg et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Treatment endpoints of participants with diffuse alveolar hemorrhage in anti-neutrophil cytoplasmic antibody–associated vasculitis with immunosuppression plus combinations of plasmapheresis (i.e., plasma exchange [PLEX]) versus no plasmapheresis (no PLEX) and standard versus reduced-dose steroids (i.e., glucocorticoids [GCs]). The endpoints focused on comparative mortality, ventilator-free days, and rates of serious infection at 1 year between the treatment groups. Participants were randomized to undergo PLEX plus standard GCs, PLEX plus reduced GCs, no PLEX plus standard GCs, and no PLEX plus reduced GCs. Created using BioRender.com.
See this image and copyright information in PMC

Comment on

References

    1. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med . 1988;318:1651–1657. - PubMed
    1. Da Silva RC, Adhikari P. Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage: a systematic review. Cureus . 2022;14:e29909. - PMC - PubMed
    1. Lauque D, Cadranel J, Lazor R, Pourrat J, Ronco P, Guillevin L, et al. Microscopic polyangiitis with alveolar hemorrhage. A study of 29 cases and review of the literature. Groupe d’Etudes et de Recherche sur les Maladies “Orphelines” Pulmonaires (GERM“O”P) Medicine (Baltimore) . 2000;79:222–233. - PubMed
    1. Guillevin L, Durand-Gasselin B, Cevallos R, Gayraud M, Lhote F, Callard P, et al. Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. Arthritis Rheum . 1999;42:421–430. - PubMed
    1. Fussner LA, Flores-Suárez LF, Cartin-Ceba R, Specks U, Cox PG, Jayne DRW, et al. Alveolar hemorrhage in ANCA-associated vasculitis: results of an international, randomized, controlled trial (PEXIVAS) Am J Respir Crit Care Med . 2024;209:1141–1151. - PMC - PubMed

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