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Editorial
. 2024 May 1;209(9):1064-1066.
doi: 10.1164/rccm.202402-0287ED.

The Fats and the Furious: Unraveling the Role of Macrophage Lipid Metabolism in Sarcoidosis

Anneka Hutton  1 , Jessy S Deshane  1
Affiliations
Editorial

The Fats and the Furious: Unraveling the Role of Macrophage Lipid Metabolism in Sarcoidosis

Anneka Hutton et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Sarcoid granuloma with a core composed of “foamy” neutral lipid–laden macrophages, demonstrating the enrichment of mechanistic target of rapamycin complex 1 (mTORC1), sterol regulatory-element binding protein 1a/c (SREBP1a/c) and its transcription factor (SREBF1), macrophage receptor with collagenous structure (MARCO), and the Janus kinase–signal transducer and activator of transcript (JAK-STAT) signaling pathways. Macrophage-derived monocytes obtained from patients with chronic sarcoidosis cluster spontaneously in vitro. Clustering and aberrant lipid metabolism is decreased after treatment with a lipoprotein-deficient serum and a statin (lovastatin). The Tsc2 knockout mice had thickening of skin overlying the hind paws and tail and increased pulmonary inflammation, which both improved after administration of a cholesterol-free diet and statin treatment. This figure was created using Biorender. GM-CSF = granulocyte-macrophage colony-stimulating factor.
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