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. 2024 May 1;44(1):210.
doi: 10.1007/s10792-024-03152-3.

The effect of adjuvant Mitomycin C during vitrectomy on functional and anatomical outcomes in patients with severe diabetic tractional retinal detachment

Ihsan Gokhan Gurelik  1 , Huseyin Baran Ozdemir  2 , Burak Acar  1
Affiliations

The effect of adjuvant Mitomycin C during vitrectomy on functional and anatomical outcomes in patients with severe diabetic tractional retinal detachment

Ihsan Gokhan Gurelik et al. Int Ophthalmol. .

Abstract

Purpose: To evaluate the effect of adjuvant Mitomycin C (MMC) use on the anatomical and functional success of vitreoretinal surgery (VRS) in severe diabetic tractional retinal detachment (dTRD) patients.

Methods: A retrospective analysis of consecutive patients undergoing VRS due to severe dTRD was conducted. Patients were categorized into those who received 20 µg/0.1 mL MMC via MMC sandwich method (Group 1) and those who did not (Group 2). Demographics, surgical characteristics, visual outcomes, and complications that may related to MMC were analyzed.

Results: A total of 25 eyes were included, 13 in Group 1 and 12 in Group 2. No statistical difference was observed in baseline characteristics between the groups. The mean best-corrected visual acuity was 1.90 ± 0.43 logMAR and 1.93 ± 0.41 logMAR preoperatively and 1.60 ± 0.78 logMAR and 1.56 ± 0.78 logMAR postoperatively in Groups 1 and 2, respectively (p = 0.154). The postoperative mean intraocular pressure was 16.23 ± 2.55 mmHg and 13.08 ± 4.94 mmHg in Groups 1 and 2, respectively (p = 0.225). The rate of re-surgery was significantly lower in Group 1 (0% vs. 41.7% in Group 2, p = 0.015). Retina was attached in all patients at the last visit. No MMC-related complication was recorded.

Conclusion: Intraoperative adjuvant MMC application for severe dTRD significantly reduces re-surgery rates with good anatomical and functional outcomes safely.

Keywords: Fibrovascular proliferation; Mitomycin C; Proliferative diabetic retinopathy; Vitrectomy.

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References

    1. The Diabetic Retinopathy Vitrectomy Study Research Group (1988) Early vitrectomy for severe proliferative diabetic retinopathy in eyes with useful vision; clinical application of results of a randomized trial:diabetic retinopathy vitrectomy study report 4. Ophthalmology 95(10):1321–1334. https://doi.org/10.1016/s0161-6420(88)33014-9 - DOI
    1. La Heij EC, Tecim S, Kessels AG, Liem AT, Japing WJ, Hendrikse F (2004) Clinical variables and their relation to visual outcome after vitrectomy in eyes with diabetic retinal traction detachment. Graefes Arch Clin Exp Ophthalmol 242:210–217 - DOI - PubMed
    1. Meleth AD, Carvounis PE (2014) Outcomes of vitrectomy for tractional retinal detachment in diabetic retinopathy. Int Ophthalmol Clin 54(2):127–139 - DOI - PubMed
    1. McCullough P, Mohite A, Virgili G, Lois N (2023) Outcomes and complications of pars plana vitrectomy for tractional retinal detachment in people with diabetes: a systematic review and meta-analysis. JAMA Ophthalmol 141(2):186–195. https://doi.org/10.1001/jamaophthalmol.2022.5817 - DOI - PubMed - PMC
    1. Al-Khersan H, Venincasa MJ, Kloosterboer A, Sridhar J, Smiddy WE, Townsend JH et al (2020) Pars plana vitrectomy reoperations for complications of proliferative diabetic retinopathy. Clin Ophthalmol (Auckland, NZ) 14:1559–1563. https://doi.org/10.2147/opth.s252285 - DOI

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