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Meta-Analysis
. 2024 May 1;19(5):e0301374.
doi: 10.1371/journal.pone.0301374. eCollection 2024.

Association between PM10 exposure and risk of myocardial infarction in adults: A systematic review and meta-analysis

Kleiton Strobl  1 , Syed Asad Irfan  1 , Hassan Masood  1 , Noor Latif  2 , Om Kurmi  1   3
Affiliations
Meta-Analysis

Association between PM10 exposure and risk of myocardial infarction in adults: A systematic review and meta-analysis

Kleiton Strobl et al. PLoS One. .

Abstract

Background: Air pollution has several negative health effects. Particulate matter (PM) is a pollutant that is often linked to health adversities. PM2.5 (PM with an aerodynamic diameter of ≤2.5μm) exposure has been associated with negative cardiovascular (CV) outcomes. However, the impact of PM10 (PM with an aerodynamic diameter of ≤10μm) exposure is often overlooked due to its limited ability to pass the alveolar barrier. This study aims to assess the association between PM10 exposure and risk of myocardial infarction (MI) amongst adults (≥18 years of age) as this has been poorly studied.

Methods: The study protocol was published on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023409796) on March 31, 2023. Literature searches were conducted on 4 databases (Ovid Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Web of Science) on January 17, 2023, for studies looking at associations between PM and MI. English studies from all time periods were assessed. Studies selected for review were time-series, case-crossover, and cohort studies which investigated the risk of MI as an outcome upon PM10 exposure. The quality of evidence was assessed using Cochrane's Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Data for different risk outcomes (risk ratio (RR), odds ratio (OR), hazard ratio (HR)) and 3 lags was meta-analyzed using an inverse variance statistical analysis using a random effects model. The pooled effect sizes and the 95% confidence intervals (CIs) were reported in forest plots.

Results: Among the 1,099 studies identified, 41 were included for review and 23 were deemed eligible for meta-analysis. Our analysis revealed that there is an increased risk (OR = 1.01; 95% CI:1.00-1.02) of MI with a 10 μg/m3 increase in PM10 after a lag 0 and lag 1 delay.

Conclusions: Our findings indicate that PM10 exposure is associated with an increased risk of MI. This can aid in informing environmental policy-making, personal-level preventative measures, and global public health action.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRISMA flow diagram.
Fig 2
Fig 2. Lag 0 RR for MI after 10 μg/m3 increase in PM10 exposure.
Fig 3
Fig 3. Lag 1 RR for MI after 10 μg/m3 increase in PM10 exposure.
Fig 4
Fig 4. Lag 2 RR for MI after 10 μg/m3 increase in PM10 exposure.
Fig 5
Fig 5. Lag 0 OR for MI after 10 μg/m3 increase in PM10 exposure.
Fig 6
Fig 6. Lag 1 OR for MI after 10 μg/m3 increase in PM10 exposure.
Fig 7
Fig 7. Lag 2 OR for MI after 10 μg/m3 increase in PM10 exposure.
Fig 8
Fig 8. Lag 2 HR for MI after 10 μg/m3 increase in PM10 exposure.
See this image and copyright information in PMC

References

    1. Hamanaka RB, Mutlu GM. Particulate matter air pollution: effects on the cardiovascular system. Frontiers in endocrinology. 2018. Nov 16;9:680. doi: 10.3389/fendo.2018.00680 - DOI - PMC - PubMed
    1. Particle Pollution | Air | CDC [Internet]. https://www.cdc.gov/air/particulate_matter.html
    1. Tornevi A, Olstrup H, Forsberg B. Short-term associations between PM10 and respiratory health effects in Visby, Sweden. Toxics. 2022. Jun 17;10(6):333. doi: 10.3390/toxics10060333 - DOI - PMC - PubMed
    1. Thangavel P, Park D, Lee YC. Recent insights into particulate matter (PM2. 5)-mediated toxicity in humans: an overview. International journal of environmental research and public health. 2022. Jun 19;19(12):7511. doi: 10.3390/ijerph19127511 - DOI - PMC - PubMed
    1. Nemmar A, Hoet PM, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, et al.. Passage of inhaled particles into the blood circulation in humans. Circulation. 2002. Jan 29;105(4):411–4. doi: 10.1161/hc0402.104118 - DOI - PubMed

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