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. 2024 May 2;390(17):1626-1628.
doi: 10.1056/NEJMc2400870.

Trial Update of Pitavastatin to Prevent Cardiovascular Events in HIV Infection

Steven K Grinspoon  1 , Heather J Ribaudo  2 , Pamela S Douglas  3
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Trial Update of Pitavastatin to Prevent Cardiovascular Events in HIV Infection

Steven K Grinspoon et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Treatment Effect of Pitavastatin on Major Adverse Cardiovascular Events.
Shown is the incidence of major adverse cardiovascular events (MACE) among trial participants with HIV infection in the pitavastatin group and the placebo group and the estimated treatment effect, according to stratified Cox proportional-hazards analysis (Panel A). The primary outcome of the trial is shown in bold at the top of the graph. In addition to the previously reported outcome measures, a supportive outcome measure that was limited to the hard clinical end points of myocardial infarction, stroke, and cardiovascular death (hard MACE) is presented. Cox proportional-hazards models were stratified according to sex at birth and the CD4 count at screening. Also shown are the cumulative incidence of a primary-outcome event (first MACE) (Panel B) and a key secondary outcome (first MACE or death from any cause) (Panel C). In Panels B and C, the insets show the data on an expanded y axis. Aside from the primary result, the widths of the confidence intervals have not been adjusted for multiplicity and therefore may not be used in place of hypothesis testing. TIA denotes transient ischemic attack.
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References

    1. Grinspoon SK, Fitch KV, Zanni MV, et al. Pitavastatin to prevent cardiovascular disease in HIV infection. N Engl J Med 2023;389:687–99. - PMC - PubMed
    1. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Rockville, MD: NIH Office of AIDS Research, February 2024. (https://clinicalinfo.hiv.gov/en/guide-lines/adult-and-adolescent-arv).

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