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Review
. 2024 Jun;17(2):243-255.
doi: 10.1016/j.path.2023.11.008. Epub 2023 Dec 15.

Sarcoma of the Lung and Mediastinum

Ken-Ichi Yoshida  1 , Akihiko Yoshida  2
Affiliations
Review

Sarcoma of the Lung and Mediastinum

Ken-Ichi Yoshida et al. Surg Pathol Clin. 2024 Jun.

Abstract

Primary sarcoma of the lung and mediastinum is rare. The diagnosis requires careful exclusion of sarcomatoid carcinoma, sarcomatoid mesothelioma, and metastases from extra-thoracic sites. This review summarizes the key morphologic, immunohistochemical, and molecular characteristics of sarcomas that are encountered in the lung and mediastinum. The tumor types discussed are synovial sarcoma, well-differentiated/dedifferentiated liposarcoma, myxoid pleomorphic liposarcoma, intimal sarcoma of the pulmonary artery, inflammatory myofibroblastic tumor, epithelioid hemangioendothelioma, primary pulmonary myxoid sarcoma, malignant peripheral nerve sheath tumor, Ewing sarcoma, and CIC-rearranged sarcoma. Relevant differential diagnoses are also addressed.

Keywords: Diagnosis; Lung; Mediastinum; Sarcoma.

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Conflict of interest statement

Disclosure This work was supported in part by JSPS, JapanKAKENHI, Japan (Grant Numbers JP21K06919). The authors have nothing to disclose pertaining to this work.

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