Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2024 Sep-Oct;100(5):539-543.
doi: 10.1016/j.jped.2024.03.012. Epub 2024 Apr 30.

Inhaled magnesium versus inhaled salbutamol in rescue treatment for moderate and severe asthma exacerbations in pediatric patients

Michelle Siqueira Debiazzi  1 , Rossano César Bonatto  1 , Fábio Joly Campos  1 , Joelma Gonçalves Martin  1 , José Roberto Fioretto  1 , Maria Letícia das Neves Hansen  1 , Arthur Martins de Araújo Luz  1 , Haroldo Teófilo de Carvalho  2
Affiliations
Randomized Controlled Trial

Inhaled magnesium versus inhaled salbutamol in rescue treatment for moderate and severe asthma exacerbations in pediatric patients

Michelle Siqueira Debiazzi et al. J Pediatr (Rio J). 2024 Sep-Oct.

Abstract

Objective: To compare the effectiveness of inhaled Magnesium Sulfate associated with Salbutamol versus Inhaled Salbutamol alone in patients with moderate and severe asthma exacerbations.

Method: Clinical, prospective and randomized study with patients between 3 and 14 years of age divided into two groups: one to receive inhaled salbutamol associated with magnesium sulfate (GSM), the other to receive inhaled salbutamol alone (GS). The sample consisted of 40 patients, 20 patients in each group. Severity was classified using the modified Wood-Downes score, with values between 4 and 7 classified as moderate and 8 or more classified as severe.

Results: Post-inhalation scores decreased both in patients who received salbutamol and magnesium and in those who received salbutamol alone, with no statistically significant difference between the groups.

Conclusions: Despite the benefits when administered intravenously, inhalation of the drug alone or in combination did not reduce the severity of the exacerbation.

Keywords: Asthma; Exacerbation; Pediatrics.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest, and they each contributed fully to the preparation of this manuscript.

Comment in

References

    1. Bai T.R., Vonk J.M., Postma D.S., Boezen H. Severe exacerbations predict excess lung function decline in asthma. Eur Respir J. 2007;30:452–456. - PubMed
    1. O'Byrne P.M., Pedersen S., Lamm C.J., Tan W.C., Busse W.W. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med. 2009;179:19–24. - PubMed
    1. Johnston N.W., Johnston S.L., Norman G.R., Dai J., Sears M.R. The September epidemic of asthma hospitalization: school children as disease vectors. J Allergy Clin Immunol. 2006;117:557–562. - PubMed
    1. Baraldo S., Contoli M., Bazzan E., Turato G., Padovani A., Marku B. Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma. J Allergy Clin Immunol. 2012;130:1307–1314. - PubMed
    1. Permaul P., Hoffman E., Fu C., Sheehan W., Baxi S., Gaffin J. Allergens in urban schools and homes of children with asthma. Pediatr Allergy Immunol. 2012;23:543–549. - PMC - PubMed

Publication types