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Review
. 2024 Apr 30;22(1):409.
doi: 10.1186/s12967-024-05191-x.

Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis

Yili Chen #  1 , Wen Zhao #  2 , An Hu  2 , Shi Lin  2 , Ping Chen  1 , Bing Yang  1 , Zhirong Fan  1 , Ji Qi  1 , Wenhui Zhang  1 , Huanhuan Gao  1 , Xiubing Yu  1 , Haiyun Chen  1 , Luyuan Chen  3 , Haizhou Wang  4
Affiliations
Review

Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis

Yili Chen et al. J Transl Med. .

Abstract

With the aging global population, type 2 diabetes mellitus (T2DM) and osteoporosis(OP) are becoming increasingly prevalent. Diabetic osteoporosis (DOP) is a metabolic bone disorder characterized by abnormal bone tissue structure and reduced bone strength in patients with diabetes. Studies have revealed a close association among diabetes, increased fracture risk, and disturbances in iron metabolism. This review explores the concept of ferroptosis, a non-apoptotic cell death process dependent on intracellular iron, focusing on its role in DOP. Iron-dependent lipid peroxidation, particularly impacting pancreatic β-cells, osteoblasts (OBs) and osteoclasts (OCs), contributes to DOP. The intricate interplay between iron dysregulation, which comprises deficiency and overload, and DOP has been discussed, emphasizing how excessive iron accumulation triggers ferroptosis in DOP. This concise overview highlights the need to understand the complex relationship between T2DM and OP, particularly ferroptosis. This review aimed to elucidate the pathogenesis of ferroptosis in DOP and provide a prospective for future research targeting interventions in the field of ferroptosis.

Keywords: Diabetic osteoporosis; Ferroptosis; Osteoporosis; Reactive oxygen species; Type 2 diabetes mellitus.

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Conflict of interest statement

The author confirms that no generative AI or AI-assisted technologies were used to assist in writing during the preparation of this work. The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.

Figures

Fig. 1
Fig. 1
Map of ferroptosis
Fig. 2
Fig. 2
Osteoporotic ferroptosis
Fig. 3
Fig. 3
Ferroptosis occurs in pancreatic β-cells
Fig. 4
Fig. 4
Ferroptosis in DOP
See this image and copyright information in PMC

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