Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr 16:35:100440.
doi: 10.1016/j.jctube.2024.100440. eCollection 2024 May.

Management of M. abscessus subsp. abscessus early-onset prosthetic joint infection: Case report and literature review

Giovanni Mori  1   2 , Paolo Scarpellini  3 , Filippo Masera  4 , Stefania Torri  5 , Antonella Castagna  1   3 , Monica Guffanti  3
Affiliations
Review

Management of M. abscessus subsp. abscessus early-onset prosthetic joint infection: Case report and literature review

Giovanni Mori et al. J Clin Tuberc Other Mycobact Dis. .

Abstract

Nontuberculous mycobacteria are a rare but still emerging cause of difficult-to-treat prosthetic joint infection. To our knowledge only 17 cases of M. abscessus complex prosthetic joint infection are reported in literature, of which only 1 is by M. abscessus subps. abscessus. No guidelines are available for this clinical scenario. We describe a 68-years-old female patient with an early-onset M. abscessus subsp. abscessus prosthetic joint infection, successfully treated with a tailored medical-surgical strategy, and present an overview of cases currently available in the literature to assist physicians in the management of these uncommon infections.

Keywords: Antibiotic resistance; M. abscessus subsp. abscessus; Nontuberculous mycobacteria; Prosthetic joint infection.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Laboratory investigations, medical and surgical interventions. Abbreviations: AMK = amikacin, CFX = cefoxitine, CFZ = clofazimine, CRP = C-reactive protein, eGFR = estimated glomerular filtration rate, IMP = imipenem, LNZ = linezolid, PE = polyethylene, REA = resection arthroplasty.
See this image and copyright information in PMC

References

    1. Tande A.J., Patel R. Prosthetic joint infection. Clin Microbiol Rev. 2014;27(2):302–345. - PMC - PubMed
    1. Beam E., Osmon D. Prosthetic joint infection update. Infect Dis Clin North Am. 2018;32(4):843–859. - PubMed
    1. Del Pozo J.L., Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med. 2009;361(8):787–794. - PMC - PubMed
    1. Azzam K., Parvizi J., Jungkind D., Hanssen A., Fehring T., Springer B., et al. Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutional experience. J Bone Joint Surg Am. 2009;91(Supplement_6):142–149. - PubMed
    1. Santoso A., Phatama K.Y., Rhatomy S., Budhiparama N.C. Prosthetic joint infection of the hip and knee due to Mycobacterium species: a systematic review. World J Orthop. 2022;13(5):503–514. - PMC - PubMed

LinkOut - more resources