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Review
. 2024 Apr 17:15:1393274.
doi: 10.3389/fneur.2024.1393274. eCollection 2024.

High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram

Dmitry Alexandrovich Chegodaev  1 , Polina Alekseevna Pavlova  2
Affiliations
Review

High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram

Dmitry Alexandrovich Chegodaev et al. Front Neurol. .

Abstract

Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesis of brain disorders that are primarily related to focal EEG slowing. An attempt is made to trace the hypothetical link between this EEG pattern and focal cerebral tissue lactacidosis.

Keywords: acidosis; electroencephalogram; epilepsy; focal slowing; lactate; structural lesions.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of possible mechanisms by which lactate can lead to hyperpolarization, decreasing neuronal activity, and the generation of EEG slowing as a consequence.
See this image and copyright information in PMC

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