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Review
. 2024 Apr 17:15:1364948.
doi: 10.3389/fphar.2024.1364948. eCollection 2024.

Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities

Yumei Wang #  1 , Qing Ai #  1   2 , Meiling Gu  1   2 , Hong Guan  3 , Wenqin Yang  3 , Meng Zhang  1   2 , Jialin Mao  1 , Zhao Lin  1 , Qi Liu  1 , Jicheng Liu  1
Affiliations
Review

Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities

Yumei Wang et al. Front Pharmacol. .

Abstract

Morus alba L., a common traditional Chinese medicine (TCM) with a centuries-old medicinal history, owned various medicinal parts like Mori folium, Mori ramulus, Mori cortex and Mori fructus. Different medical parts exhibit distinct modern pharmacological effects. Mori folium exhibited analgesic, anti-inflammatory, hypoglycemic action and lipid-regulation effects. Mori ramulus owned anti-bacterial, anti-asthmatic and diuretic activities. Mori cortex showed counteraction action of pain, inflammatory, bacterial, and platelet aggregation. Mori fructus could decompose fat, lower blood lipids and prevent vascular sclerosis. The main chemical components in Morus alba L. covered flavonoids, phenolic compounds, alkaloids, and amino acids. This article comprehensively analyzed the recent literature related to chemical components and pharmacological actions of M. alba L., summarizing 198 of ingredients and described the modern activities of different extracts and the bioactive constituents in the four parts from M. alba L. These results fully demonstrated the medicinal value of M. alba L., provided valuable references for further comprehensive development, and layed the foundation for the utilization of M. alba L.

Keywords: Mori cortex; Mori folium; Mori fructus; Mori ramulus; chemical constituents; pharmacological activities.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Phenols.
FIGURE 2
FIGURE 2
Alkaloids.
FIGURE 3
FIGURE 3
Coumarins.
FIGURE 4
FIGURE 4
Carbohydrates.
FIGURE 5
FIGURE 5
Terpenoids.
FIGURE 6
FIGURE 6
Organic acids.
FIGURE 7
FIGURE 7
Anthocyanin.
FIGURE 8
FIGURE 8
Other categories.
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References

    1. Agus H. H., Cetin A., Ozdemir N., Ozbay M. G., Caglar M. A., Sariyildiz M. A., et al. (2022). Resorcinol alleviates alpha-terpineol-induced cell death in Schizosaccharomyces pombe via increased activity of the antioxidant enzyme Sod2. FEMS Yeast Res. 22 (1), foac052. 10.1093/femsyr/foac052 - DOI - PubMed
    1. Ai J., Bao B., Battino M., Giampieri F., Chen C., You L., et al. (2021). Recent advances on bioactive polysaccharides from mulberry. Food Funct. 12 (12), 5219–5235. 10.1039/d1fo00682g - DOI - PubMed
    1. Alavi D. S., Farkhondeh T., Aschner M., Darroudi M., Samini H., Samarghandian S. (2023). Chrysin effect against gastric cancer: focus on its molecular mechanisms. Curr. Molec. Pharmacol. 16 (7), 707–711. 10.2174/1874467216666230103105725 - DOI - PubMed
    1. Alibakhshi A., Malekzadeh R., Hosseini S. A., Yaghoobi H. (2023). Investigation of the therapeutic role of native plant compounds against colorectal cancer based on system biology and virtual screening. Sci. Rep. 13 (1), 11451. 10.1038/s41598-023-38134-5 - DOI - PMC - PubMed
    1. Al-Kuraishy H. M., Al-Gareeb A. I., Negm W. A., Alexiou A., Batiha G. E. (2022). Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective. Inflammopharmacology 30 (5), 1493–1501. 10.1007/s10787-022-01038-3 - DOI - PMC - PubMed