SGLT2 inhibitors: not every drug has the same effect

Alexander Staruschenko^{1

2

3}

Affiliations

¹ Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, United States.
² Hypertension and Kidney Research Center, University of South FloridaTampa, Florida, United States.
³ James A. Haley Veterans Hospital, Tampa, Florida, United States.

Free article

Editorial

Alexander Staruschenko. Am J Physiol Renal Physiol. 2024.

Free article

. 2024 Jun 1;326(6):F1039-F1040.

doi: 10.1152/ajprenal.00126.2024. Epub 2024 May 2.

Alexander Staruschenko^{1

2

3}

¹ Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, United States.
² Hypertension and Kidney Research Center, University of South FloridaTampa, Florida, United States.
³ James A. Haley Veterans Hospital, Tampa, Florida, United States.

No abstract available

Keywords: NHE3; SGLT2 inhibitors; canagliflozin; empagliflozin; proximal tubule.

Comment on

SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake.
Albalawy WN, Youm EB, Shipman KE, Trull KJ, Baty CJ, Long KR, Rbaibi Y, Wang XP, Fagunloye OG, White KA, Jurczak MJ, Kashlan OB, Weisz OA. Albalawy WN, et al. Am J Physiol Renal Physiol. 2024 Jun 1;326(6):F1041-F1053. doi: 10.1152/ajprenal.00005.2024. Epub 2024 Apr 25. Am J Physiol Renal Physiol. 2024. PMID: 38660713 Free PMC article.