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Editorial
. 2024 Sep;71(3):257-258.
doi: 10.1165/rcmb.2024-0166ED.

Long Story Short: Understanding Isoform-Specific Expression of FAM13A

Cera A McDonald  1 , Ryan A Langlois  1
Affiliations
Editorial

Long Story Short: Understanding Isoform-Specific Expression of FAM13A

Cera A McDonald et al. Am J Respir Cell Mol Biol. 2024 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Under wild-type conditions (left), the beating of cilia generates a current in the pulmonary mucus, clearing environmental contaminants from the lungs. In the model proposed by Howes and colleagues (right), FAM13A knockdown disrupts the actin cytoskeleton supporting the base of the cilia, resulting in impaired beating and the slower clearance or accumulation of environmental contaminants in the mucus and potentially contributing to the onset of chronic obstructive pulmonary disease.
See this image and copyright information in PMC

Comment on

  • The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport.
    Howes A, Rogerson C, Belyaev N, Karagyozova T, Rapiteanu R, Fradique R, Pellicciotta N, Mayhew D, Hurd C, Crotta S, Singh T, Dingwell K, Myatt A, Arad N, Hasan H, Bijlsma H, Panjwani A, Vijayan V, Young G, Bridges A, Petit-Frere S, Betts J, Larminie C, Smith JC, Hessel EM, Michalovich D, Walport L, Cicuta P, Powell AJ, Beinke S, Wack A. Howes A, et al. Am J Respir Cell Mol Biol. 2024 Sep;71(3):282-293. doi: 10.1165/rcmb.2024-0063OC. Am J Respir Cell Mol Biol. 2024. PMID: 38691660 Free PMC article.

References

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