Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jul;101(1):3-9.
doi: 10.1111/cen.15069. Epub 2024 May 2.

Diagnostic challenges in patients with reninomas and extrarenal renin-producing tumours

Botond Fabian  1 , Oskar Ragnarsson  2   3   4 , Aleksandar Prazic  5 , Mikael Rydén  6 , Cristina Volpe  7 , Ola Lindgren  1   8
Affiliations
Review

Diagnostic challenges in patients with reninomas and extrarenal renin-producing tumours

Botond Fabian et al. Clin Endocrinol (Oxf). 2024 Jul.

Abstract

Renin-secreting tumours are rare causes of secondary hypertension and hypokalaemia. They are usually surgically curable, hence proper diagnostic work-up and tumour localisation is essential. In this paper, we present three Swedish patients recently diagnosed with renin secreting tumours, two with reninomas and one with an extrarenal renin-producing tumour, to illustrate diagnostic challenges. We also discuss the biochemical work-up, the pros and cons of different imaging techniques (computer tomography [CT], magnetic resonance imaging and [18F]fluorodeoxyglucose-positron emission tomography-CT), as well as how renal vein sampling (RVC) may contribute to localisation of the tumour.

Keywords: aldosterone; extrarenal renin‐production; juxtaglomerular cell tumour; renal vein catheterisation; renin; reninoma; secondary hypertension.

PubMed Disclaimer

References

REFERENCES

    1. Robertson PW, Klidjian A, Harding LK, Walters G, Lee MR, Robb‐Smith AHT. Hypertension due to a renin‐secreting renal tumour. Am J Med. 1967;43(6):963‐976. doi:10.1016/0002-9343(67)90256-2
    1. Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L. Reninoma: case report and literature review. J Hypertens. 2008;26(2):368‐373. doi:10.1097/HJH.0b013e3282f283f3
    1. Mao J, Wang Z, Wu X, Dai W, Tong A. Recurrent hypertensive cerebral hemorrhages in a boy caused by a reninoma: rare manifestations and distinctive electron microscopy findings. Johns Hopkins Med J. 2012;14(11):802‐805. doi:10.1111/jch.12015
    1. Phillis C, Midenberg E, O'Connor M, Terry Jr. W, Keel C, Noh P. Juxtaglomerular cell tumor: a rare presentation of a surgically curable cause of secondary hypertension in the pediatric population. Urology. 2021;156:e131‐e133. doi:10.1016/j.urology.2021.05.030
    1. Osawa S, Hosokawa Y, Soda T, et al. Juxtaglomerular cell tumor that was preoperatively diagnosed using selective renal venous sampling. Intern Med. 2013;52(17):1937‐1942. doi:10.2169/internalmedicine.52.0395

LinkOut - more resources