A reverse brake for the cell cycle

Bart Westendorp^{1

2}

Affiliations

¹ Department of Biomolecular Health Sciences, Division Cell Biology, Metabolism and Cancer, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
² Regenerative Medicine Center Utrecht, Utrecht, Netherlands.

Comment

Bart Westendorp. Science. 2024.

. 2024 May 3;384(6695):512-513.

doi: 10.1126/science.adp1866. Epub 2024 May 2.

Bart Westendorp^{1

2}

¹ Department of Biomolecular Health Sciences, Division Cell Biology, Metabolism and Cancer, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
² Regenerative Medicine Center Utrecht, Utrecht, Netherlands.

Abstract

Mitogenic signaling acts beyond S-phase entry to prevent whole-genome duplications.

CDK4/6 activity is required during G₂ arrest to prevent stress-induced endoreplication.
McKenney C, Lendner Y, Guerrero Zuniga A, Sinha N, Veresko B, Aikin TJ, Regot S. McKenney C, et al. Science. 2024 May 3;384(6695):eadi2421. doi: 10.1126/science.adi2421. Epub 2024 May 3. Science. 2024. PMID: 38696576 Free PMC article.