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Review
. 2024 May;59(5):e14580.
doi: 10.1111/rda.14580.

Potential role of oxidative stress in pathogenesis of benign prostatic hyperplasia in male dogs

Anna Domosławska-Wyderska  1 , Sławomir Zduńczyk  1 , Agata Rafalska  1
Affiliations
Review

Potential role of oxidative stress in pathogenesis of benign prostatic hyperplasia in male dogs

Anna Domosławska-Wyderska et al. Reprod Domest Anim. 2024 May.

Abstract

The pathogenesis of benign prostatic hyperplasia (BPH) in dogs is still not fully understood. Some studies suggest that oxidative stress may have a potential role in the pathogenesis of BPH in dogs. Age-related hormonal changes may activate a chronic inflammatory response in the prostate. This causes the generation of reactive oxygen species (ROS) and results in oxidative stress. Excessive production of ROS results in DNA damage and hyperplastic transformation of prostatic cells. The use of antioxidants for improvement of treatment outcomes for canine PBH has been discussed. Further research is needed on the importance of oxidative stress in the development of BPH in dogs and the usefulness of antioxidants in the supportive treatment of this condition.

Keywords: antioxidants; benign prostatic hyperplasia; dog; oxidative stress.

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