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. 2024 Jul;70(1):101-110.
doi: 10.1002/mus.28098. Epub 2024 May 3.

Whole-body magnetic resonance neurography in patients with chronic inflammatory demyelinating polyneuropathy

Davood Fathi  1 , Ali Naraghi  2   3 , Lawrence M White  2   3 , Dubravka Dodig  4 , Carolina Barnett-Tapia  5 , Ari Breiner  6 , Vera Bril  5 , Hans D Katzberg  5
Affiliations

Whole-body magnetic resonance neurography in patients with chronic inflammatory demyelinating polyneuropathy

Davood Fathi et al. Muscle Nerve. 2024 Jul.

Abstract

Introduction/aims: Whole-body magnetic resonance neurography (MRN) is an imaging modality that shows peripheral nerve signal change in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We aimed to explore the diagnostic potential of whole-body MRN and its potential as a monitoring tool after immunotherapy in treatment-naïve CIDP patients.

Methods: Whole-body MRN using coronal 3-dimensional short tau inversion recovery (STIR) sampling perfection with application-optimized contrasts by using different flip angle evolution (SPACE) techniques was performed in patients being investigated for CIDP and in healthy controls. Baseline clinical neuropathy scales and electrophysiologic parameters were collected, and MRN findings were compared before and after CIDP treatment.

Results: We found highly concordant symmetrical thickening and increased T2 signal intensities in the brachial/lumbosacral plexus, femoral, or sciatic nerves in five of the eight patients with a final diagnosis of CIDP and none of the healthy controls. There were no treatment-related imaging changes in five patients with CIDP who completed a follow-up study. Diffuse, symmetrical thickening, and increased T2 signal in root, plexus, and peripheral nerves were found in two patients ultimately excluded due to a diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome in addition to signal changes in the muscles, bony lesions, organomegaly, and lymphadenopathy.

Discussion: Whole-body MRN imaging shows promise in detecting abnormalities in proximal nerve segments in patients with CIDP. Future studies evaluating the role of MRN in assessing treatment response should consider follow-up scans after treatment durations of more than 4 months.

Keywords: CIDP; MR neurography; MRI; demyelination; inflammatory neuropathy.

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References

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