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Review
. 2024 Apr 23:38:101715.
doi: 10.1016/j.bbrep.2024.101715. eCollection 2024 Jul.

Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases

Lan Li  1 , Xin Zhou  2 , Wene Liu  2 , Zhen Chen  2 , Xiaoqin Xiao  1   2 , Guiming Deng  2
Affiliations
Review

Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases

Lan Li et al. Biochem Biophys Rep. .

Abstract

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme involved in many pathophysiological processes. Supplementation with NAD+ and its precursors has been demonstrated as an emerging therapeutic strategy for the diseases. NAD+ also plays an important role in the reproductive system. Here, we summarize the function of NAD+ in various reproductive diseases and review the application of NAD+ and its precursors in the preservation of reproductive capacity and the prevention of embryonic malformations. It is shown that NAD+ shows good promise as a therapeutic approach for saving reproductive capacity.

Keywords: Female reproduction; Gynecologic tumor; NAD+; NAD+ precursors; Nicotinamide adenine dinucleotide; Ovarian diseases.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
The biosynthesis process of NAD+.
Fig. 2
Fig. 2
NAD + precursors protect the ovary by improving mitochondrial function, lowering ROS levels, reducing oxidative damage, and inhibiting DNA damage and apoptosis.
Fig. 3
Fig. 3
NAD + precursors rescue PCOS by improving insulin resistance, inflammation and mitochondrial function.
See this image and copyright information in PMC

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