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. 2024 Apr 21;10(9):e29926.
doi: 10.1016/j.heliyon.2024.e29926. eCollection 2024 May 15.

Prevention and treatment of anthracycline-induced cardiotoxicity: A bibliometric analysis of the years 2000-2023

Yifan Kong  1 , Xiaohong Wei  1 , Di Zhang  2 , Hongyuan Lin  3 , Mengqi Peng  4 , Hongcai Shang  1   3   4
Affiliations

Prevention and treatment of anthracycline-induced cardiotoxicity: A bibliometric analysis of the years 2000-2023

Yifan Kong et al. Heliyon. .

Abstract

Aims: This study aimed to evaluate the global research trend in the prevention and treatment of cardiotoxicity caused by anthracyclines from 2000 to 2023, and to explore international cooperation, research hotspots, and frontier trends.

Methods: The articles on the prevention and treatment of anthracycline-induced cardiotoxicity published from 2000 to 2023 were searched by Web of Science. The bibliometrics software CiteSpace was used for visual analysis of countries, institutions, journals, authors, cited authors, cited references, and keywords.

Results: This study analyzed the current status of global research on the prevention and treatment of cardiotoxicity caused by anthracyclines. A total of 3,669 papers were searched and 851 studies were included. The number of publications increased gradually throughout the years. Cardiovascular Toxicology (15) is the journal with the most publications. Circulation (547) ranked first among cited journals. In this field, the country with the most publications is the United States (229), and the institution with the most publications is Charles Univ Prague (18). In the analysis of the authors, Tomas S (10) ranked first. Cardinale D (262) ranked first among cited authors. In the ranking of cited literature frequency, the article ranked first is "Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy" (121). The keywords "heart failure" (215) and "oxidative stress" (212) were the most frequent. "Enalapril", "inflammation", "cell death", "NF-κB" and "Nrf2" were the advanced research contents in 2019-2023.

Conclusions: This study provided valuable information for cardio-oncology researchers to identify potential collaborators and institutions, discover hot topics, and explore new research directions. The prevention and treatment of anthracycline-induced cardiotoxicity focuses on early detection and timely treatment. The results of the current clinical studies on the treatment of anthracycline-induced cardiotoxicity are contradictory, and more studies are needed to provide more reliable clinical evidence in the future.

Keywords: Anthracyclines; Bibliometric analysis; Cardiotoxicity; CiteSpace.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Literature search process.
Fig. 2
Fig. 2
The number of publications from 2000 to 2022.
Fig. 3
Fig. 3
A country cooperation map from 2000 to 2023.
Fig. 4
Fig. 4
A co-author map from 2000 to 2023.
Fig. 5
Fig. 5
A cited author map from 2000 to 2023.
Fig. 6
Fig. 6
A keyword co-occurrence map from 2000 to 2023.
Fig. 7
Fig. 7
Top 47 keywords with the strongest citation bursts.
See this image and copyright information in PMC

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References

    1. Henson K.E., Reulen R.C., Winter D.L., Bright C.J., Fidler M.M., Frobisher C., Guha J., Wong K.F., Kelly J., Edgar A.B., McCabe M.G., Whelan J., Cutter D.J., Darby S.C., Hawkins M.M. Cardiac mortality among 200 000 five-year survivors of cancer diagnosed at 15 to 39 Years of age: the teenage and Young adult cancer survivor study. Circulation. 2016;134(20):1519–1531. - PMC - PubMed
    1. Ellahham S., Khalouf A., Elkhazendar M., Dababo N., Manla Y. An overview of radiation-induced heart disease. Radiat. Oncol. J. 2022;40(2):89–102. - PMC - PubMed
    1. Herrmann J., Lenihan D., Armenian S., Barac A., Blaes A., Cardinale D., Carver J., Dent S., Ky B., Lyon A.R., Lopez-Fernandez T., Fradley M.G., Ganatra S., Curigliano G., Mitchell J.D., Minotti G., Lang N.N., Liu J.E., Neilan T.G., Nohria A., O'Quinn R., Pusic I., Porter C., Reynolds K.L., Ruddy K.J., Thavendiranathan P., Valent P. Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement. Eur. Heart J. 2022;43(4):280–299. - PMC - PubMed
    1. Zamorano J.L., Lancellotti P., Rodriguez M.D., Aboyans V., Asteggiano R., Galderisi M., Habib G., Lenihan D.J., Lip G., Lyon A.R., Lopez F.T., Mohty D., Piepoli M.F., Tamargo J., Torbicki A., Suter T.M. ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: the Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC) Eur. Heart J. 2016;37(36):2768–2801. 2016. - PubMed
    1. Narezkina A., Nasim K. Anthracycline cardiotoxicity. Circ Heart Fail. 2019;12(3) - PubMed

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