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Review
. 2024 Apr 18:15:1389558.
doi: 10.3389/fgene.2024.1389558. eCollection 2024.

The occurrence and development of induced pluripotent stem cells

Yi Chen  1 , Meng Li  1 , Yanqing Wu  1
Affiliations
Review

The occurrence and development of induced pluripotent stem cells

Yi Chen et al. Front Genet. .

Abstract

The ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc (OSKM), known as "Yamanaka factors," can reprogram or stimulate the production of induced pluripotent stem cells (iPSCs). Although OSKM is still the gold standard, there are multiple ways to reprogram cells into iPSCs. In recent years, significant progress has been made in improving the efficiency of this technology. Ten years after the first report was published, human pluripotent stem cells have gradually been applied in clinical settings, including disease modeling, cell therapy, new drug development, and cell derivation. Here, we provide a review of the discovery of iPSCs and their applications in disease and development.

Keywords: OSKM; epigenetic barriers; iPSCs; induced pluripotent stem cells; reprogram.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanism and clinical application of iPSCs.
FIGURE 2
FIGURE 2
Epigenetic barriers on cell reprogramming.
FIGURE 3
FIGURE 3
Representative disease modeling utilizing iPSCs.
See this image and copyright information in PMC

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