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. 2024;19(8):655-665.
doi: 10.2217/fmb-2023-0227. Epub 2024 May 3.

Effect of silver vanadate on the antibiofilm, adhesion and biocompatibility properties of denture adhesive

Graziele C Alvim  1 , Viviane de C Oliveira  2 , Andréa C Dos Reis  2 , Marco A Schiavon  3 , Marcelo R Pinto  1 , Marcos V da Silva  4 , César P Lepri  1 , Denise T de Castro  1
Affiliations

Effect of silver vanadate on the antibiofilm, adhesion and biocompatibility properties of denture adhesive

Graziele C Alvim et al. Future Microbiol. 2024.

Abstract

Aim: To evaluate the biological and mechanical properties of an adhesive with nanostructured silver vanadate (AgVO3). Materials & methods: Specimens in poly(methyl methacrylate) (PMMA) were treated with Ultra Corega Cream (UCCA) denture adhesive with or without AgVO3. Biofilms of Candida albicans, Candida glabrata and Streptococcus mutans were grown and the viable cells counted. Fluorescence microscopy was used. The viability of the VERO cell and adhesive strength were evaluated. Results: All concentrations of AgVO3 reduced the biofilm formation and showed no cytotoxic effect. At 5 min and 24 h, UCCA with 5 and 10% AgVO3 showed better performance, respectively. Conclusion: AgVO3 promoted the antibiofilm activity of the adhesive, with a positive effect on the adhesive strength, and was biocompatible.

Keywords: adhesion; biocompatibility test; biofilm; dental prosthesis; denture adhesive; nanotechnology.

Plain language summary

What is this summary about? Some people wear false teeth called dentures. They use a special glue to keep these false teeth in their mouths. It is important to clean dentures well and remove the glue every day. If the dentures get dirty, they can cause infections of the gums. Doctors and dentists can help, but sometimes medicines do not work well. This study checked to see whether adding a medicine that can kill bacteria into the glue could stop gum swelling and other illnesses, or make them better.What were the results? The glue containing the medicine killed microbes like fungi and bacteria. It also stuck things together well and was safe to use.What do the results mean? Using this special glue could help people with dentures to avoid illness.

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Study flowchart. *AgVO3: Nanostructured silver vanadate decorated with silver nanoparticle; PMMA: Poly(methyl methacrylate) (PMMA)-based resin; UCCA: Ultra Corega cream adhesive.
Figure 2.
Figure 2.
Transmission electron microscopy of nanostructured silver vanadate decorated with silver nanoparticles.
Figure 3.
Figure 3.
Fluorescence microscopy of C. albicans, C. glabrata and S. mutans biofilm (63×). Viable cells marked in green and dead cells marked in red. *AgVO3: Nanostructured silver vanadate decorated with silver nanoparticle; PMMA: Poly(methyl methacrylate) (PMMA)-based resin; UCCA: Ultra Corega cream adhesive.
Figure 4.
Figure 4.
Cell viability of the VERO cell line for 24 h. Data are expressed as mean and standard deviation. (A) Cells treated with Ultra Corega cream containing different concentrations of AgVO3. (B) Cells treated with different concentrations of AgVO3. Cells maintained only in the presence of RPMI 1640 culture medium were used as controls. *Indicates statistically significant difference compared with cells maintained in RPMI 1640 (p < 0.05; ANOVA test). AgVO3: Nanostructured silver vanadate decorated with silver nanoparticle; UCCA: Ultra Corega cream adhesive.
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