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Published Erratum
. 2024 Aug;27(3):375-377.
doi: 10.1007/s10456-024-09919-7.

Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization

Gideon Obasanmi  1 , Manjosh Uppal  1 , Jing Z Cui  1 , Jeanne Xi  1 , Myeong Jin Ju  1   2 , Jun Song  2 , Eleanor To  1 , Siqi Li  1 , Wania Khan  1 , Darian Cheng  1 , John Zhu  1 , Lyden Irani  1 , Isa Samad  1 , Julie Zhu  1 , Hyung-Suk Yoo  1 , Alexandre Aubert  3   4 , Jonathan Stoddard  5 , Martha Neuringer  5 , David J Granville  3   4 , Joanne A Matsubara  6
Affiliations
Published Erratum

Correction: Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization

Gideon Obasanmi et al. Angiogenesis. 2024 Aug.
No abstract available

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Figures

Fig. 3
Fig. 3
GzmB degrades the extracellular matrix and promotes inflammation in the RPE-Choroid. A, C, E Western blot reveals cleavage of extracellular matrix proteins by exogenous GzmB. Representative western blot of ECM proteins in CSA supernatant for A fibronectin; C laminin and E decorin. Note cleavage bands at lower molecular weight, identified by the red box and arrow in A (fibronectin) and C (laminin). Vinculin bands are shown as loading controls. B, D, F Densitometric quantification of degradation by western blot—the additional cleavage bands at lower molecular weight were quantified. B Fibronectin; D laminin and F decorin. Results are presented as mean ± SEM. *p < 0.05, ***p < 0.001 in T-test. n = 4 per group. G, I Next, we tested pro-inflammatory cytokines by western blot in CSA supernatant after exogenous GzmB. Representative western blot of inflammatory cytokines in CSA supernatant: G IL-6; I TGF-β. H, J Densitometric quantification of western blots. H IL-6; J TGF-β. K, L Two additional pro-inflammatory cytokines were quantified by MSD multiplex assay: K IL-6; L CCL2. Results are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 in T-test. n = 4–6 per group
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