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. 2024 Aug;35(8):1201-1212.
doi: 10.1007/s10552-024-01878-0. Epub 2024 May 3.

Associations between subjective social status and predictors of interest in genetic testing among women diagnosed with breast cancer at a young age

Jonathan N Odumegwu #  1 , Daniel Chavez-Yenter #  2   3 , Melody S Goodman  1 , Kimberly A Kaphingst  4   5
Affiliations

Associations between subjective social status and predictors of interest in genetic testing among women diagnosed with breast cancer at a young age

Jonathan N Odumegwu et al. Cancer Causes Control. 2024 Aug.

Abstract

Purpose: Genetic testing for gene mutations which elevate risk for breast cancer is particularly important for women diagnosed at a young age. Differences remain in access and utilization to testing across social groups, and research on the predictors of interest in genetic testing for women diagnosed at a young age is limited.

Methods: We examined the relationships between subjective social status (SSS) and variables previously identified as possible predictors of genetic testing, including genome sequencing knowledge, genetic worry, cancer worry, health consciousness, decision-making preferences, genetic self-efficacy, genetic-related beliefs, and subjective numeracy, among a cohort of women who were diagnosed with breast cancer at a young age.

Results: In this sample (n = 1,076), those who had higher SSS had significantly higher knowledge about the limitations of genome sequencing (Odds Ratio (OR) = 1.11; 95% CI = 1.01-1.21) and significantly higher informational norms (OR = 1.93; 95% CI = 1.19-3.14) than those with lower SSS. Similarly, education (OR = 2.75; 95% CI = 1.79-4.22), health status (OR = 2.18; 95% CI = 1.44-3.31) were significant predictors among higher SSS women compared to lower SSS women in our multivariate analysis. Lower SSS women with low self-reported income (OR = 0.13; 95% CI = 0.08-0.20) had lower odds of genetic testing interest. Our results are consistent with some prior research utilizing proxy indicators for socioeconomic status, but our research adds the importance of using a multidimensional indicator such as SSS to examine cancer and genetic testing predictor outcomes.

Conclusion: To develop interventions to improve genetic knowledge, researchers should consider the social status and contexts of women diagnosed with breast cancer at a young age (or before 40 years old) to ensure equity in the distribution of genetic testing benefits.

Keywords: Breast cancer; Genetic testing; Subjective Social Status; Young women.

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