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. 2024 May 4;41(6):134.
doi: 10.1007/s12032-024-02333-5.

A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways

Md Rezaul Islam  1 , Abdur Rauf  2 , Shopnil Alash  1 , Md Naeem Hossain Fakir  1 , Gazi Kaifeara Thufa  1 , Mahbuba Sharmin Sowa  1 , Dattatreya Mukherjee  3 , Harendra Kumar  4 , Md Sadique Hussain  5 , Abdullah S M Aljohani  6 , Muhammad Imran  7 , Waleed Al Abdulmonem  8 , Rekha Thiruvengadam  9 , Muthu Thiruvengadam  10
Affiliations

A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways

Md Rezaul Islam et al. Med Oncol. .

Abstract

Primary liver cancer is a type of cancer that develops in the liver. Hepatocellular carcinoma is a primary liver cancer that usually affects adults. Liver cancer is a fatal global condition that affects millions of people worldwide. Despite advances in technology, the mortality rate remains alarming. There is growing interest in researching alternative medicines to prevent or reduce the effects of liver cancer. Recent studies have shown growing interest in herbal products, nutraceuticals, and Chinese medicines as potential treatments for liver cancer. These substances contain unique bioactive compounds with anticancer properties. The causes of liver cancer and potential treatments are discussed in this review. This study reviews natural compounds, such as curcumin, resveratrol, green tea catechins, grape seed extracts, vitamin D, and selenium. Preclinical and clinical studies have shown that these medications reduce the risk of liver cancer through their antiviral, anti-inflammatory, antioxidant, anti-angiogenic, and antimetastatic properties. This article discusses the therapeutic properties of natural products, nutraceuticals, and Chinese compounds for the prevention and treatment of liver cancer.

Keywords: Anticancer; Chinese herbal medicines; Liver cancer; Metastasis; Natural products; Treatment.

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References

    1. Islami F, Miller KD, Siegel RL, Zheng Z, Zhao J, Han X, Ma J, Jemal A, Yabroff KR. National and state estimates of lost earnings from cancer deaths in the United States. JAMA Oncol. 2019;5(9):e191460–e191460. - PubMed - PMC - DOI
    1. MacLachlan JH, Cowie BC. Liver cancer is the fastest increasing cause of cancer death in Australians. Med J Aust. 2012;197(9):492–3. - PubMed - DOI
    1. Anwanwan D, Singh SK, Singh S, Saikam V, Singh R. Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta (BBA) Rev Cancer. 2020;1873(1):188314. - DOI
    1. Criss CR, Makary MS. Recent advances in image-guided locoregional therapies for primary liver tumors. Biology. 2023;12(7):999. - PubMed - PMC - DOI
    1. Zhang X-F, Bian J-C, Zhang X-Y, Zhang Z-M, Jiang F, Wang Q-M, Wang Q-J, Cao Y-Y, Tang B-M. Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China? World j gastroenterol WJG. 2005;11(10):1457. - PubMed - DOI

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