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Review
. 2024 May;37(4):865-879.
doi: 10.1007/s40620-024-01927-6. Epub 2024 May 4.

The mechanisms of ferroptosis in the pathogenesis of kidney diseases

Jia Liu  1 , Jianheng Chen  2 , Jie Lv  2 , Yuhang Gong  3 , Jie Song  4
Affiliations
Review

The mechanisms of ferroptosis in the pathogenesis of kidney diseases

Jia Liu et al. J Nephrol. 2024 May.

Abstract

The pathological features of acute and chronic kidney diseases are closely associated with cell death in glomeruli and tubules. Ferroptosis is a form of programmed cell death characterized by iron overload-induced oxidative stress. Ferroptosis has recently gained increasing attention as a pathogenic mechanism of kidney damage. Specifically, the ferroptosis signaling pathway has been found to be involved in the pathological process of acute and chronic kidney injury, potentially contributing to the development of both acute and chronic kidney diseases. This paper aims to elucidate the underlying mechanisms of ferroptosis and its role in the pathogenesis of kidney disease, highlighting its significance and proposing novel directions for its treatment.

Keywords: Ferroptosis; Iron; Kidney disease; Lipid peroxidation; Oxidative stress.

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