Melatonin use in managing insomnia in children with autism and other neurogenetic disorders - An assessment by the international pediatric sleep association (IPSA)

Affiliations

¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: kotagal.suresh@mayo.edu.
² Departments of Neurology and Pediatrics, Sleep Disorders Division, Vanderbilt University Medical Center, Nashville, TN, USA.
³ Université Paris Cité, NeuroDiderot, INSERM, 75019, Paris, France.
⁴ Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵ Pediatric Neurologist and Sleep Medicine MD MsC, Universidad Nacional de Colombia. Sleep Lab Coordinator at HOMI Fundacion, Bogota, Colombia.
⁶ Universidad Nacional de Colombia and Sleep Medicine, Universidad Nacional Autónoma de México. Sleep Lab Coordinator at Neuroconexión, Armenia, Colombia.
⁷ Psychology and Paediatric Sleep, Appleton Institute of Behavioural Science, CQUniversity Australia, Adelaide, Australia; School of Educational Psychology and Counselling, Faculty of Education, Monash University, Melbourne, Australia.
⁸ Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M4S 2V6, Ontario, Canada.
⁹ Interdisciplinary Sleep Program & BC Children's Hospital Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Department of Pediatrics, Medical University of Vienna, Austria 938 W 28th Avenue Vancouver, Vienna, BC, V5Z 4H4, Australia.
¹⁰ Dept of Developmental and Social Psychology, Sapienza University, Via dei Marsi 78, 00185, Rome, Italy.
¹¹ Centre for Paedatric Sleep Disorders, Pediatric Department, General Hospital Celje, University of Maribor, Oblakova ulica 5, 3000, Celje, Slovenia.
¹² Sleep Center, Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, USA; Department of Pediatric, University of Cincinnati College of Medicine, Cincinnati, 3333 Burnet Ave, MLC 7041, OH, USA, Cincinnati, OH, 45229, USA.
¹³ Titular de Neurologia da Escola de Medicina, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Brain Institute (InsCer), Brazil.
¹⁴ Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.

PMID: 38704869
DOI: 10.1016/j.sleep.2024.04.008

Melatonin use in managing insomnia in children with autism and other neurogenetic disorders - An assessment by the international pediatric sleep association (IPSA)

Suresh Kotagal et al. Sleep Med. 2024 Jul.

. 2024 Jul:119:222-228.

doi: 10.1016/j.sleep.2024.04.008. Epub 2024 Apr 20.

Authors

Affiliations

¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: kotagal.suresh@mayo.edu.
² Departments of Neurology and Pediatrics, Sleep Disorders Division, Vanderbilt University Medical Center, Nashville, TN, USA.
³ Université Paris Cité, NeuroDiderot, INSERM, 75019, Paris, France.
⁴ Department of Developmental and Behavioral Pediatrics, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
⁵ Pediatric Neurologist and Sleep Medicine MD MsC, Universidad Nacional de Colombia. Sleep Lab Coordinator at HOMI Fundacion, Bogota, Colombia.
⁶ Universidad Nacional de Colombia and Sleep Medicine, Universidad Nacional Autónoma de México. Sleep Lab Coordinator at Neuroconexión, Armenia, Colombia.
⁷ Psychology and Paediatric Sleep, Appleton Institute of Behavioural Science, CQUniversity Australia, Adelaide, Australia; School of Educational Psychology and Counselling, Faculty of Education, Monash University, Melbourne, Australia.
⁸ Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M4S 2V6, Ontario, Canada.
⁹ Interdisciplinary Sleep Program & BC Children's Hospital Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Department of Pediatrics, Medical University of Vienna, Austria 938 W 28th Avenue Vancouver, Vienna, BC, V5Z 4H4, Australia.
¹⁰ Dept of Developmental and Social Psychology, Sapienza University, Via dei Marsi 78, 00185, Rome, Italy.
¹¹ Centre for Paedatric Sleep Disorders, Pediatric Department, General Hospital Celje, University of Maribor, Oblakova ulica 5, 3000, Celje, Slovenia.
¹² Sleep Center, Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, USA; Department of Pediatric, University of Cincinnati College of Medicine, Cincinnati, 3333 Burnet Ave, MLC 7041, OH, USA, Cincinnati, OH, 45229, USA.
¹³ Titular de Neurologia da Escola de Medicina, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Brain Institute (InsCer), Brazil.
¹⁴ Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.

PMID: 38704869
DOI: 10.1016/j.sleep.2024.04.008

Abstract

Though it is widely prescribed for improving sleep of children with autism and other neurogenetic disorders, there is a need for practical guidance to clinicians on the use of melatonin for managing insomnia in this population. Because data were either lacking or inconclusive, a task force was established by the International Pediatric Sleep Association (IPSA) to examine the literature based on clinical trials from 2012 onwards. A summary of evidence pertaining to melatonin's utility and potential side effects, practice-related caveats, and insights for use are published herewith.

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Conflict of interest statement

Declaration of competing interest I do not have any conflict of interests to disclose regarding this work. Members of the task force have submitted their disclosures separately to the office of the World Sleep Society.

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Melatonin use in managing insomnia in children with autism and other neurogenetic disorders - An assessment by the international pediatric sleep association (IPSA)

Affiliations

Melatonin use in managing insomnia in children with autism and other neurogenetic disorders - An assessment by the international pediatric sleep association (IPSA)

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical