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Review
. 2024 Apr 29:18:1399-1414.
doi: 10.2147/DDDT.S463177. eCollection 2024.

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Quan Hu #  1 , Yingxiao Li #  2 , Zhaochen Lin  3 , Hao Zhang  4 , Haoyue Chen  4 , Cui Chao  3 , Chuanliang Zhao  5
Affiliations
Review

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Quan Hu et al. Drug Des Devel Ther. .

Abstract

Hydrogen, which is a novel biomedical molecule, is currently the subject of extensive research involving animal experiments and in vitro cell experiments, and it is gradually being applied in clinical settings. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, and antiapoptotic effects, thus exhibiting considerable protective effects in various diseases. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI). This paper provides a comprehensive review of the potential molecular biology mechanisms of hydrogen therapy and its application in treating SCI, with an aim to better explore the medical value of hydrogen and provide new avenues for the adjuvant treatment of SCI.

Keywords: anti-inflammatory; hydrogen; selective antioxidant; spinal cord injury.

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Conflict of interest statement

The authors report no competing interests in this work.

Figures

Figure 1
Figure 1
Molecular action mechanism of hydrogen in biology.
Figure 2
Figure 2
Advantages of hydrogen therapy in treating spinal cord injury.
Figure 3
Figure 3
Methods of hydrogen delivery.
Figure 4
Figure 4
Protective effect of hydrogen on spinal cord injury and its possible molecular mechanism.
See this image and copyright information in PMC

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