Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2024 Jun;177(6):eL230113.
doi: 10.7326/L24-0113. Epub 2024 May 7.

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians (Version 1, Update Alert)

Amir Qaseem  1 , Lauri A Hicks  2 , Itziar Etxeandia-Ikobaltzeta  1 , Tatyana A Shamliyan  1 , Thomas G Cooney  3 ; Clinical Guidelines Committee of the American College of Physicians; Ethan Balk, J. Thomas Cross Jr, Nick Fitterman, Jennifer S. Lin, Michael Maroto, Matthew C. Miller, Adam J. Obley, Douglas K. Owens, Paul G. Shekelle, Jeffrey A. Tice, Janice E. Tufte, Jennifer Yost
Collaborators, Affiliations
Practice Guideline

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians (Version 1, Update Alert)

Amir Qaseem et al. Ann Intern Med. 2024 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclosures: All financial and intellectual disclosures of interest were declared, and potential conflicts were discussed and managed. Dr. Wilt was recused from authorship and voting due to a moderate-level conflict (household member recently authored relevant publications and served on the topic expert panel for supporting systematic review). Dr. Crandall was recused from authorship and voting due to moderate-level conflicts (recently authored relevant publications). A record of disclosures of interest and management of conflicts is kept for each Clinical Guidelines Committee meeting and conference call and can be viewed at www.acponline.org/clinical_information/guidelines/guidelines/conflicts_cgc.htm. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L24-0113.

Figures

Figure.
Figure.
Current recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults (version 1, update alert) (1). ACP = American College of Physicians; PTH = human parathyroid hormone; RANK = receptor activator of nuclear factor κB.
See this image and copyright information in PMC

Comment on

References

    1. Qaseem A, Hicks LA, Etxeandia-Ikobaltzeta I, et al.; Clinical Guidelines Committee of the American College of Physicians. Pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults: a living clinical guideline from the American College of Physicians. Ann Intern Med. 2023;176:224–238. doi:10.7326/M22-1034 - DOI - PMC - PubMed
    1. Mori S, Hagino H, Sugimoto T, et al. Sequential therapy with once-weekly teriparatide injection followed by alendronate versus monotherapy with alendronate alone in patients at high risk of osteoporotic fracture: final results of the Japanese Osteoporosis Intervention Trial-05. Osteoporos Int. 2023;34:189–199. doi:10.1007/s00198-022-06570-0 - DOI - PMC - PubMed
    1. Liu F-C, Luk K-C, Chen Y-C. Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: a multi-institutional retrospective cohort study in Taiwan. Osteoporos Int. 2023;34:1729–1737. doi:10.1007/s00198-023-06818-3 - DOI - PMC - PubMed
    1. Imai T, Hosoi T, Hagino H, et al. Antiresorptive drugs and the risk of femoral shaft fracture in men and women with osteoporosis: a cohort study using the National Database of Health Insurance Claims of Japan. J Epidemiol. 2023;33:633–639. doi:10.2188/jea.JE20220099 - DOI - PMC - PubMed
    1. Everts-Graber J, Lehmann D, Burkard J-P, et al. Risk of osteonecrosis of the jaw under denosumab compared to bisphosphonates in patients with osteoporosis. J Bone Miner Res. 2022;37:340–348. doi:10.1002/jbmr.4472 - DOI - PubMed

MeSH terms

Substances